One-Year Outcomes of the SAVE Study: Sirolimus as a Therapeutic Approach for UVEitis

Translational Vision Science & Technology
Mohamed A IbrahimQuan Dong Nguyen

Abstract

To determine the efficacy and safety of repeated intravitreal and subconjunctival administrations of sirolimus in patients with noninfectious uveitis at 1 year in the Sirolimus as a Therapeutic Approach UVEitis (SAVE) Study. Open-label, prospective, and randomized interventional clinical trial in which 30 patients with noninfectious intermediate, posterior, or panuveitis were randomized 1:1 to receive sirolimus 352-μg intravitreal or 1320-μg subconjunctival. Sirolimus was administered at days 0, 60, and 120. At month 6, all subjects were allowed to receive sirolimus at intervals greater than or equal to 2 months and until month 12. Changes in vitreous haze (VH), visual acuity (VA), and retinal thickness at month 12 were compared with baseline. Of patients with active uveitis at baseline (n = 20), 70% showed greater than or equal to 2 steps reduction of VH at month 12 (P < 0.05), 88% (n = 7) of patients with inactive uveitis at baseline showed either no change or reduction of VH to no haze, 36% (n = 10) of all patients (n = 28) gained greater than or equal to one line of VA, 21% (n = 6) lost greater than or equal to 1 line, and 43% (n = 12) showed no change. At the end of 1 year, no statistical differences in efficacy were found...Continue Reading

References

Apr 25, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M G AtturA R Amin
Oct 10, 2001·Therapeutic Drug Monitoring·K L Napoli, P J Taylor
Mar 27, 2002·The British Journal of Ophthalmology·A P Adamis
Jul 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonia M JoussenAnthony P Adamis
Nov 18, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas G NührenbergDietlind Zohlnhöfer
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Jun 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rebecca J RobertsChristopher J E Watson
Jan 21, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sofia Sofroniadou, David Goldsmith
Apr 19, 2011·Targeted Oncology·Scott A SoefjeAndrew J Brenner
May 14, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nupura KrishnadevCatherine Meyerle
Sep 29, 2011·Clinical Journal of Oncology Nursing·Amy Potter PilotteNathaniel Treister
Apr 3, 2012·American Journal of Ophthalmology·H Nida SenRobert B Nussenblatt

❮ Previous
Next ❯

Citations

Nov 26, 2015·Expert Opinion on Pharmacotherapy·Uwe Pleyer, Stephan R Thurau
Dec 8, 2015·Expert Opinion on Investigational Drugs·Raquel Salazar-MéndezMiguel Cordero-Coma
Apr 14, 2016·Ocular Immunology and Inflammation·Denis WakefieldStephan Thurau
Apr 3, 2019·Clinical & Experimental Ophthalmology·Muhammad HassanQuan D Nguyen
Feb 27, 2019·Journal of Pediatric Hematology/oncology·Luisa Cortellazzo WielAlberto Tommasini
Dec 6, 2019·Expert Opinion on Drug Safety·Maria Soledad OrmaecheaQuan Dong Nguyen
Nov 21, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Mayara Rodrigues Brandão De PaivaArmando Silva-Cunha
Sep 15, 2015·Current Opinion in Ophthalmology·Claudia Fabiani, Jorge L Alió
May 6, 2020·Therapeutics and Clinical Risk Management·Thomas El JammalPascal Sève
Aug 23, 2020·Indian Journal of Ophthalmology·Hitesh AgrawalMudit Tyagi
Dec 27, 2018·International Ophthalmology Clinics·Shilpa Kodati, Christina Y Weng
Jan 7, 2021·AAPS PharmSciTech·Mayara Rodrigues Brandão De PaivaArmando Silva-Cunha
Jun 23, 2020·Ophthalmology·Pauline T MerrillUNKNOWN Sirolimus Study Assessing Double-Masked Uveitis Treatment (SAKURA) Study Group
Jan 26, 2021·Expert Review of Clinical Pharmacology·Ogugua Ndili ObiRobert P Baughman
Jan 30, 2021·Asia-Pacific Journal of Ophthalmology·Yi Hsuan LiShwu-Jiuan Sheu
Oct 12, 2021·Journal of Ophthalmic Inflammation and Infection·Rocco Luigi ModugnoCarlos Pavesio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.