One-Year Postapproval Clinical Experience with Radium-223 Dichloride in Patients with Metastatic Castrate-Resistant Prostate Cancer

Cancer Biotherapy & Radiopharmaceuticals
Hossein JadvarPeter S Conti

Abstract

We report our 1-year postapproval clinical experience with Radium-223 dichloride for treatment of castrate-resistant prostate cancer with bone metastases. The clinical courses of the first 25 patients treated were reviewed retrospectively. Incidence of hematologic, gastrointestinal, and other adverse events were identified, including those events that led to cessation or delay in treatment. Alterations in bone pain and serum alkaline phosphatase and prostate-specific antigen (PSA) levels were evaluated. Six patients received all 6 scheduled doses of Radium-223 dichloride, 2 completed 5 doses, 6 received 4 doses, 2 completed 3 doses, 6 patients had 2 doses, and 3 patients received one dose, for a total of 91 doses administered. Nine patients discontinued treatment after receiving at least one dose due to progressive disease, 5 required blood transfusions, 5 developed gastrointestinal symptoms, 4 reported worsening bone pain, and 1 developed dermatitis. Downward trends in serum alkaline phosphatase and PSA were seen in 11 and 5 patients, respectively. About one-quarter of cohort completed the entire six-dose treatment. Advancing soft tissue disease was the primary reason for cessation of therapy. The adverse events were mild and ...Continue Reading

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Citations

Dec 20, 2015·Journal of the National Cancer Institute·Diane S AbouDaniel L J Thorek
Apr 8, 2016·Clinical Genitourinary Cancer·Dipenkumar ModiElisabeth I Heath
Apr 29, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Luigia FlorimonteLorenzo Stefano Maffioli
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Apr 11, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Diane S AbouDaniel Lj Thorek

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT00699751

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