One-Year Postoperative Mortality in MEN1 Patients Operated on Gastric and Duodenopancreatic Neuroendocrine Tumors: An AFCE and GTE Cohort Study

World Journal of Surgery
Niki ChristouPierre Goudet

Abstract

In MEN1 patients with gastric and duodenopancreatic neuroendocrine tumors (GPD-NET), surgery aims to control secretions or to prevent metastatic spread, but after GPD-NET resection, postoperative mortality may be related to the surgery itself or to other associated MEN1 lesions with their own uncontrolled secretions or metastatic behavior. To analyze the causes of death within 1 year following a GPD-NET resection in MEN1 patients. An observational study collecting data from the Groupe d'étude des Tumeurs Endocrines (GTE) database. The analysis considered the time between surgery and death (early deaths [<1 month after surgery] versus delayed deaths [beyond 1 month after surgery]) and the period (before 1990 vs after 1990). Causes of death were classified as related to GDP surgery, related to surgery for other MEN1 lesions or not related to MEN1 causes. GTE database which includes 1220 MEN1 patients and 441 GPD-NET resections. Four hundred and forty-one GPD-NET resections. The primary end point was postoperative mortality within 1 year after surgery. Twenty-four patients met the inclusion criteria (2%). Median age at death was 50.5 years. Sixteen deaths occurred in the 30-day postoperative period (76%). Among the 8 delayed death...Continue Reading

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Citations

Dec 12, 2019·Expert Review of Anticancer Therapy·Elisabeth HainSébastien Gaujoux
Feb 11, 2021·Nature Reviews. Endocrinology·Abdallah Al-SalamehPhilippe Chanson
Apr 12, 2021·Annales d'endocrinologie·Aurore GeslotDelphine Vezzosi

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