One-year protocol liver biopsy can stratify fibrosis progression in liver transplant recipients with recurrent hepatitis C infection

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Roberto J FirpiDavid R Nelson

Abstract

Determinants of progression to cirrhosis in hepatitis C virus (HCV) infection have been well described in the immunocompetent population but remain poorly defined in liver transplant (LT) recipients. This cohort study determines the factors contributing to the development of fibrosis and its rate of progression in the allograft. Predictive factors analyzed include: demographics, host and donor factors, surgery-related variables (cold and warm ischemia time), rejection episodes, cytomegalovirus infection (CMV), and immunosuppression. Over 12 years, 842 adult LTs were performed at our institution; 358 for the indication of HCV. A total of 264 patients underwent protocol liver biopsies at month 4 and yearly after LT. Using the modified Knodell system of Ishak for staging fibrosis, the median fibrosis progression rate was .8 units/year (P < .001). Rapid fibrosis progression (> .8 units/year) was best identified by liver histology performed at 1 year. Donor age > 55 years was associated with rapid fibrosis progression and development of cirrhosis (P < .001). In contrast, donor age < 35 years was associated with slower progression of fibrosis (P = .003). Risk factors for graft loss due to recurrent HCV included recipient age > 35 yea...Continue Reading

References

Apr 1, 1992·The Journal of Clinical Investigation·C FérayC Bréchot
Feb 1, 1990·Transplantation·W J WallM Bloch
Oct 19, 1989·The New England Journal of Medicine·T E StarzlD Van Thiel
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Mar 28, 1996·The New England Journal of Medicine·E J GaneR Williams
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HoofnagleK M Detre
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CharltonJ Hoofnagle
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PrietoJ Berenguer
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R SreekumarM R Charlton
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina BerenguerJoaquín Berenguer
Nov 9, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Roberto J FirpiDavid R Nelson
May 13, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael Charlton
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Manal F AbdelmalekDavid R Nelson

❮ Previous
Next ❯

Citations

Jul 26, 2012·Seminars in Immunopathology·Giacomo GermaniAndrew K Burroughs
Apr 9, 2008·Journal of Hepato-biliary-pancreatic Surgery·Sumihito Tamura, Yasuhiko Sugawara
Jan 12, 2013·Digestive Diseases and Sciences·Anthony J MichaelsRoberto J Firpi
Nov 26, 2010·Journal of Gastrointestinal Cancer·Ivan Zendejas-RuizRobin D Kim
Mar 22, 2006·Current Opinion in Gastroenterology·Adnan Said, Michael R Lucey
Sep 26, 2006·Annals of Surgery·Andrew M CameronRonald W Busuttil
Apr 7, 2007·Current Opinion in Gastroenterology·Adnan SaidMichael R Lucey
Jun 14, 2012·Advances in Anatomic Pathology·Nadia OvchinskyJoel E Lavine
May 8, 2008·The American Journal of Surgical Pathology·Susan C AbrahamAlyssa M Krasinskas
Jun 27, 2008·Transplantation·George Mells, James Neuberger
Jun 30, 2012·Transplantation·Jennifer E LaydenNina M Clark
Apr 13, 2007·Drugs·Mazen AlsatiePaul Y Kwo
Apr 15, 2006·International Journal of Medical Sciences·Thomas D Schiano, Paul Martin
Mar 25, 2014·World Journal of Gastroenterology : WJG·Francesco VasuriAntonia D'Errico-Grigioni
Apr 8, 2014·World Journal of Gastroenterology : WJG·Renumathy Dhanasekaran, Roberto J Firpi
Aug 19, 2014·Clinics and Research in Hepatology and Gastroenterology·Armelle Poujol-RobertRaoul Poupon
Jul 16, 2014·Nature Reviews. Gastroenterology & Hepatology·Deepak JoshiKosh Agarwal
May 30, 2013·Infectious Disease Clinics of North America·Geeta S Karnik, Kirti Shetty
Jan 16, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Francesco VasuriAntonia D'Errico-Grigioni
Mar 20, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca S BelliGiovambattista Pinzello
Jun 11, 2010·Transplantation Proceedings·T M ManziaG Tisone
Oct 12, 2007·Journal of Hepatology·Marco VivarelliAntonio Daniele Pinna
Jul 4, 2007·Clinics in Liver Disease·Marina Berenguer
Jul 7, 2007·Archives of Medical Research·Marco Antonio Olivera-Martínez, Juan F Gallegos-Orozco
Jul 29, 2009·Histopathology·Cinzia BorgognaMario Pirisi
Jun 10, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Sandeep Mukherjee, Elizabeth Lyden
Nov 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Laura LladóUNKNOWN THOSIN Study Group
Nov 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nazia SelznerEberhard L Renner
Jan 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Roniel CabreraGiuseppe Morelli
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M BerenguerM Prieto
Nov 15, 2006·Clinical Transplantation·Martin F SprinzlMarcus Schuchmann
Jul 10, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Jean F BothaAlan N Langnas
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C-K HuiT L Wright
Feb 27, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C RockeyUNKNOWN American Association for the Study of Liver Diseases
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Edward J Gane

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Marina BerenguerJoaquín Berenguer
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Marina BerenguerTeresa L Wright
© 2021 Meta ULC. All rights reserved