One-year safety and quality of life outcomes in patients with atrial fibrillation on dronedarone: prospective, non-interventional study in German ambulatory care

Herzschrittmachertherapie & Elektrophysiologie
Andreas GoetteRalph F Bosch

Abstract

The multichannel blocker dronedarone is currently indicated for the maintenance of sinus rhythm after successful cardioversion in adult clinically stable patients with paroxysmal or persistent atrial fibrillation (AF), with careful monitoring of cardiac, hepatic and renal function. We aimed to investigate patients' quality of life (QoL) and tolerability and effectiveness of dronedarone under real life conditions. In the 1-year prospective, non-interventional IMPULS study, 161 office-based cardiologists, general practitioners and internists throughout Germany documented 549 patients with AF who were currently or newly prescribed dronedarone (safety set, SS). Of those, 342 patients (full analysis set, FAS) provided data on QoL at baseline, 6 months and 12 months). Mean age of patients was 67.6/66.3 years; 53.0 %/57.3 % were men (SS/FAS). AF type at inclusion in the SS/FAS was paroxysmal in 71.9 %/71.3 % and persistent in 26.0 %/26.6 % (missing in 2.0 %/2.0 %). The proportion of patients in sinus rhythm increased from 44.6 % at baseline to 70.2 % (SS). The mean value on the 100-point visual analogue scale (EuroQol EQ-5D) increased from 62.3 ± 17.1 at baseline by 11.4 ± 18.7 points (FAS, p<0.0001). The AF-QoL Psychological Domain i...Continue Reading

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Citations

Apr 9, 2019·Journal of the American Heart Association·Linn Arvidsson StrømnesInger Ariansen
Mar 23, 2017·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Frank HäßlerDavid Pittrow
Feb 12, 2019·Acta Neurologica Scandinavica·Bo-Lin HoA-Ching Chao
Jul 22, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe BorianiA John Camm
Aug 31, 2020·The American Journal of Cardiology·Earl L GoehringGerald V Naccarelli

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Software Mentioned

IMPULS
Multaq®
MOVE
ATHENA
ATRIUM
SAS

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