One-year study of occupational human immunodeficiency virus postexposure prophylaxis

Journal of Occupational and Environmental Medicine
James Robert Garb

Abstract

A 12-month experience with human immunodeficiency virus (HIV) postexposure prophylaxis (PEP) in a tertiary care center was evaluated for timeliness of treatment and adherence to treatment recommendations. Forty-six health care workers were started on HIV PEP. Risk status of the source patient, rather than type of exposure, was a significant determinant for both initiating and completing treatment. Of those exposed to HIV-positive sources, 79% completed the full 28 days of therapy. Only 22% of all health care workers who started PEP discontinued treatment because of adverse effects. Excluding three cases with significant delays in reporting and one in which treatment was controversial, the mean time from exposure to first dose of PEP was 1 hour and 46 minutes. The use of a defined treatment protocol, with supporting educational material and PEP medication immediately available, is an effective way of managing HIV exposures.

References

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Citations

Jan 8, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Roland C MerchantKenneth H Mayer
Aug 7, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·David T KuharUNKNOWN US Public Health Service Working Group
May 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nathan FordZara Shubber

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