One-Year Survival Worse for Lung Retransplants Relative to Primary Lung Transplants.

The Annals of Thoracic Surgery
Simran K RandhawaVarun Puri

Abstract

Outcomes after lung retransplantation (LRT) remain inferior compared with primary lung transplantation (PLT). This study examined the impact of center volume on 1-year survival after LRT. Using the United Network for Organ Sharing database, the study abstracted patients undergoing PLT and LRT between January 2006 and December 2017, excluding combined heart-lung transplants and multiple retransplants. One-year survival rates after PLT and LRT were compared using propensity score matching. In the LRT cohort, multivariable Cox models with and without time-dependent coefficients were fitted to examine association between transplant center volume and 1-year survival. Center volume was categorized on the basis of inspection of restricted cubic splines. A total of 20,675 recipients (PLT 19,853 [96.0%] vs LRT 822 [4.0%]) were included. One-year survival was lower for LRT recipients in the matched cohort (PLT 84.8% vs LRT 76.7%). There was steady improvement in 1-year survival after LRT (2006 to 2009 72.1% vs 2010 to 2013 76.6% vs 2014 to 2017 80.1%). Higher center volume was associated with better 1-year survival after LRT. This survival difference was noted in the initial 30 days after transplantation (intermediate vs low volume hazar...Continue Reading

References

Nov 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·R J NovickG A Patterson
Dec 23, 2008·The Annals of Thoracic Surgery·Jeffrey H ShuhaiberRobert D Gibbons
Sep 22, 2009·The Annals of Thoracic Surgery·Eric S WeissAshish S Shah
Jan 16, 2010·Transplantation·John E ScarboroughTheodore N Pappas
Apr 23, 2011·Clinics in Chest Medicine·Michael EberleinJonathan B Orens
Oct 18, 2011·Medical Care·Amir A GhaferiJustin B Dimick
Sep 22, 2012·The Journal of Thoracic and Cardiovascular Surgery·Arman KilicAshish S Shah
Sep 23, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Roger D YusenUNKNOWN International Society for Heart and Lung Transplantation
Oct 12, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul J SpeicherMatthew G Hartwig
May 6, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S E VerledenA Haverich
Jul 5, 2015·The Annals of Thoracic Surgery·Mathew ThomasKevin P Landolfo
Jan 23, 2017·The Annals of Thoracic Surgery·Zachary N KonRichard N Pierson
Nov 5, 2017·The Annals of Thoracic Surgery·Sreeja Biswas RoyMichael A Smith
Jan 18, 2018·The Annals of Thoracic Surgery·Stephanie H ChangVarun Puri
Jun 30, 2018·Annals of Translational Medicine·Zhongheng ZhangCatharina G M Groothuis-Oudshoorn
Dec 12, 2018·Transplantation Direct·Dewei RenBrian A Bruckner
Aug 31, 2019·The Annals of Thoracic Surgery·Asishana A OshoMauricio A Villavicencio
Sep 25, 2019·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Daniel C ChambersUNKNOWN International Society for Heart and Lung Transplantation

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