One-year treatment with rosuvastatin reduces intima-media thickness in 45 hypercholesterolemic subjects with asymptomatic carotid artery disease

Pharmacology
Graziano RiccioniNicolantonio D'Orazio

Abstract

An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of our study was to evaluate whether a reduction in CIMT could be seen with 1-year treatment with rosuvastatin (10 mg/day). Forty-five patients with hypercholesterolemia and asymptomatic carotid atherosclerosis on baseline carotid ultrasound investigation (CUI) were examined with repeat CUI after 1 year of treatment (rosuvastatin 10 mg/day). Demographic and lifestyle data were collected. A physical examination was performed, and fasting venous blood samples were obtained. Total cholesterol, low-density lipoprotein cholesterol and triglycerides decreased significantly (p < 0.001), while high-density lipoprotein cholesterol increased significantly (p < 0.001) during the intervention. The mean decreases in the IMT of the right and left common carotid arteries (CCAs) were 0.29 and 0.26 mm, respectively (p < 0.05 for each). Age and lipid profile parameters were significant predictors of change in CIMT in linear regression analyses after adjustment for established atherosclerosis risk factors. One-year treatment with rosuvastatin in hypercholesterolemic adults with evidenceof subclinical atherosclerosis significantly...Continue Reading

Citations

Aug 22, 2012·Annals of Nutrition & Metabolism·Erine A Kupetsky-Rincon, Jouni Uitto
Jun 5, 2012·European Journal of Endocrinology·M D WalkerS J Silverberg
Feb 16, 2013·American Journal of Public Health·Leo R ZacharskiBruce K Chow
Apr 2, 2011·Future Cardiology·Farouk MookadamSusan Wilansky
Jun 13, 2012·Clinical and Translational Science·Erine A Kupetsky-RinconJouni Uitto
Dec 18, 2013·Clinical and Translational Science·Erine A KupetskyJouni Uitto
Jul 11, 2016·International Journal of Cardiology·Kosmas I ParaskevasFrank J Veith
May 31, 2018·The Journal of Clinical Endocrinology and Metabolism·Manuel R BlumNicolas Rodondi

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