One year's treatment of Paget's disease of bone by synthetic salmon calcitonin as a nasal spray

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
J Y ReginsterP Franchimont

Abstract

The effectiveness of synthetic salmon calcitonin (SCT) administered as a nasal spray was assessed via clinical, biological, and radiological variables in 17 previously untreated Pagetic patients over a 1-year course of therapy. The results showed a highly significant decrease of serum alkaline phosphatase (S-ALP) (p less than 0.05 after 1 month of treatment) and of the urinary hydroxyproline/creatinine ratio (OH/Cr) (p less than 0.01 after 1 month of treatment). For the whole group, the mean decrease in S-ALP was 37 +/- 4% (SEM) after 6 months (p less than 0.01) and 31 +/- 5% after 1 year (p less than 0.01). The mean fall in OH/Cr was 35 +/- 6% (SEM) (p less than 0.01) and 37 +/- 7% (p less than 0.01) after 6 and 12 months, respectively. None of the usual side-effects of SCT were reported and local tolerance was excellent throughout the study.

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Citations

Jan 1, 1990·Experimental Gerontology·J Y ReginsterP Franchimont
Nov 1, 1995·Bone·J Y Reginster, M P Lecart
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Y Reginster
Jun 27, 2002·Expert Opinion on Pharmacotherapy·Anthony DeSantis, Alan Buchman
Jan 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J Y ReginsterP Franchimont
May 1, 1995·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C RouxB Amor
Jun 8, 2017·Drug Delivery and Translational Research·Jacqueline CawthrayKishor Wasan
Mar 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Y ReginsterP Franchimont
Sep 1, 1988·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Y ReginsterP Franchimont

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