Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development

Developmental Biology
Lucie KlimovaZbynek Kozmik

Abstract

Genetic studies of the last decades strongly indicated that generation of particular retinal cell types is governed by gene regulatory networks of transcription factors and their target genes. The paired and homeodomain transcription factor Pax6 plays a pivotal role in retinal development as its inactivation in the retinal progenitor cell population leads to abolished differentiation of all retinal cell types. However, until now, only a few transcription factors operating downstream of Pax6 responsible for generation of individual retinal cell types have been identified. In this study, we identified two transcription factors of the Onecut family, Onecut1 and Onecut2, as Pax6 downstream-acting factors. Onecut1 and Onecut2 were previously shown to be expressed in developing horizontal cells, retinal ganglion cells and cone photoreceptors; however, their role in differentiation of these cell types is poorly understood. In this study, we show that the horizontal cell genesis is severely disturbed in Onecut-deficient retinae. In single Onecut1 and Onecut2 mutants, the number of horizontal cells is dramatically reduced while horizontal cells are completely missing in the Onecut1/Onecut2 compound mutant. Analysis of genes involved in ...Continue Reading

References

Jun 1, 1985·The Anatomical Record·R W Young
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·C L CepkoD Ezzeddine
Mar 31, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·W LiuM Xiang
Jan 13, 2001·Genes & Development·S W WangL Gan
Dec 19, 2003·Nucleic Acids Research·Albin SandelinBoris Lenhard
Mar 24, 2004·Seminars in Cell & Developmental Biology·Jun Hatakeyama, Ryoichiro Kageyama
Jun 14, 2005·Current Opinion in Genetics & Development·Zbynek Kozmik
Feb 14, 2006·Gastroenterology·Christophe E PierreuxFrédéric P Lemaigre
Nov 1, 2006·Development·Yoshio FujitaniChristopher V E Wright
Dec 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ross A PochéRichard R Behringer
May 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiuqian MuWilliam H Klein
Nov 14, 2008·Development·Varda Oron-KarniRuth Ashery-Padan
Jan 6, 2009·The International Journal of Developmental Biology·Kim E Haworth, Branko Latinkic
Feb 12, 2009·Genesis : the Journal of Genetics and Development·Amy N RiesenbergNadean L Brown
Sep 22, 2009·Mechanisms of Development·Hongjie ZhangMaureen Gannon
Aug 11, 2011·The Journal of Comparative Neurology·Fuguo WuXiuqian Mu
Nov 22, 2011·The Journal of Comparative Neurology·Agnès Espana, Frédéric Clotman
Mar 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Erin A BassettJudith A West-Mays
Apr 27, 2012·Molecular and Cellular Neurosciences·A Espana, F Clotman
Aug 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fuguo WuXiuqian Mu

❮ Previous
Next ❯

Citations

Aug 23, 2019·The EMBO Journal·Samuel W LukowskiRaymond Cb Wong
Mar 1, 2020·International Journal of Molecular Sciences·Yuliya Markitantova, Vladimir Simirskii
May 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Szilard SajgoTudor Constantin Badea
Apr 3, 2019·International Journal of Molecular Sciences·Lucie JaneckovaVladimir Korinek
Aug 18, 2020·Cancer Management and Research·Jie ChenChunyan Du
Jan 1, 2015·Neurogenesis·Pierre Mattar, Michel Cayouette
Dec 29, 2019·Scientific Reports·Qingyang MaXiangyin Kong
Jun 13, 2017·Frontiers in Molecular Neuroscience·Karolina U KabayizaFrédéric Clotman
Mar 31, 2021·Cellular and Molecular Life Sciences : CMLS·Jianyi Lyu, Xiuqian Mu
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Quirino Attilio VassalliAnnamaria Locascio
Aug 10, 2021·Experimental Biology and Medicine·Chen ShenXiaojun Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Fuguo WuXiuqian Mu
Proceedings of the National Academy of Sciences of the United States of America
Darshan SapkotaXiuqian Mu
© 2021 Meta ULC. All rights reserved