Ongoing Adaptive Evolution and Globalization of Sars-Cov-2.

BioRxiv : the Preprint Server for Biology
Nash D RochmanEugene V Koonin

Abstract

Unprecedented sequencing efforts have, as of October 2020, produced over 100,000 genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for the ongoing COVID-19 crisis. Understanding the trends in SARS-CoV-2 evolution is paramount to control the pandemic. Although this extensive data availability quickly facilitated the development of vaccine candidates 1 , major challenges in the analysis of this enormous dataset persist, limiting the ability of public health officials to translate science into policy. Having evolved over a short period of time, the SARS-CoV-2 isolates show low diversity, necessitating analysis of trees built from genome-scale data. Here we provide a complete ancestral genome reconstruction for SARS-CoV-2 leveraging Fitch Traceback 2 . We show that the ongoing evolution of SARS-CoV-2 over the course of the pandemic is characterized primarily by purifying selection. However, a small set of sites, including the extensively studied spike 614 3 , harbor mutations which recurred on multiple, independent occasions, indicative of positive selection. These mutations form a strongly connected network of apparent epistatic interactions. The phylogenetic tree of SARS-CoV-2 consists of...Continue Reading

Citations

Apr 18, 2021·Experimental & Molecular Medicine·Devika Singh, Soojin V Yi

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

Related Papers

BioRxiv : the Preprint Server for Biology
N. D. RochmanEugene V. Koonin
Experimental & Molecular Medicine
Devika Singh, Soojin V Yi
BioRxiv : the Preprint Server for Biology
Erik Scott WrightV. S. Cooper
MedRxiv : the Preprint Server for Health Sciences
Q. LiuHua Chen
© 2021 Meta ULC. All rights reserved