Ongoing Challenges with Healthcare-Associated Candida auris Outbreaks in Oman

Journal of Fungi
Amal Al MaaniAbdullah M S Al-Hatmi

Abstract

Candida auris has emerged in the past decade as a multi-drug resistant public health threat causing health care outbreaks. Here we report epidemiological, clinical, and microbiological investigations of a C. auris outbreak in a regional Omani hospital between April 2018 and April 2019. The outbreak started in the intensive care areas (intensive care unit (ICU), coronary care unit (CCU), and high dependency unit) but cases were subsequently diagnosed in other medical and surgical units. In addition to the patients' clinical and screening samples, environmental swabs from high touch areas and from the hands of 35 staff were collected. All the positive samples from patients and environmental screening were confirmed using MALDI-TOF, and additional ITS-rDNA sequencing was done for ten clinical and two environmental isolates. There were 32 patients positive for C. auris of which 14 (43.8%) had urinary tract infection, 11 (34.4%) had candidemia, and 7 (21.8%) had asymptomatic skin colonization. The median age was 64 years (14-88) with 17 (53.1%) male and 15 (46.9%) female patients. Prior to diagnosis, 21 (65.6%) had been admitted to the intensive care unit, and 11 (34.4%) had been nursed in medical or surgical wards. The crude mortal...Continue Reading

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Citations

May 7, 2020·Antibiotics·Martyna Mroczyńska, Anna Brillowska-Dąbrowska
Dec 22, 2019·Journal of Fungi·Jacques F Meis, Anuradha Chowdhary
Nov 26, 2020·Journal of Fungi·Wadha AlfouzanMohammad R Al-Rashidi
Dec 31, 2020·Journal of Fungi·Abdullah M S Al-HatmiDavid W Denning
May 11, 2021·Frontiers in Cellular and Infection Microbiology·Amir ArastehfarCornelia Lass-Flörl

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Methods Mentioned

BETA
PCR
electrophoresis
genotyping

Software Mentioned

GeneMapper
HPC
Excel
MAFFT
VI
BioNumerics
BLAST
Lasergene
MEGA
SeqMan

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