Ongoing loss of the tirant transposable element in natural populations of Drosophila simulans

Gene
Marie FabletCristina Vieira

Abstract

Tirant is a long terminal repeat (LTR) retrotransposon with an average of 11 insertion sites on the chromosome arms of Drosophila melanogaster flies collected from natural populations worldwide. In the sibling species Drosophila simulans, tirant is found only in African populations, which harbor a few insertion sites (1 to 5) on the chromosome arms, although some tirant sequences are present in the heterochromatin of most populations. This distribution in D. simulans reflects either the recent genomic invasion of African populations by a new variant of tirant, or a loss of tirant from the entire species apart from some sequence relics still present in Africa. In an attempt to clarify the situation, we focused on the LTR-UTR region of tirant copies from various populations of both D. melanogaster and D. simulans. We found two distinct types of regulatory region: one type was present in both D. melanogaster and D. simulans, and the other was present only in D. simulans. Copies of this latter type of tirant were transcriptionally inactive in gonads. Here we propose that the present day distribution of tirant in D. simulans populations reflects an ancient invasion of D. simulans by tirant copies followed by the loss of active copie...Continue Reading

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Citations

Mar 29, 2007·Journal of Molecular Evolution·Marie FabletCristina Vieira
Oct 7, 2006·Nature·Christian Biémont, Cristina Vieira
Jan 27, 2012·Journal of Virology·Abdou AkkoucheMarie Fablet
Apr 2, 2008·BMC Genomics·Rita RebolloCristina Vieira
Aug 22, 2012·Annual Review of Genetics·Rita RebolloDixie L Mager
Jan 17, 2017·Scientific Reports·Hélène Lopez-MaestreCristina Vieira
Jan 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marie FabletCristina Vieira
Apr 11, 2020·Ecology and Evolution·Sarah Signor
Nov 29, 2020·Molecular Biology and Evolution·Florian SchwarzRobert Kofler
Jun 1, 2020·Trends in Genetics : TIG·Erin S KelleherJustin P Blumenstiel

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