PMID: 20127038Feb 4, 2010Paper

Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo

International Journal of Molecular Medicine
Jae-We ChoKyu-Suk Lee

Abstract

A scar is usually developed by an imbalance of collagen synthesis and degradation. It is believed that the flavonoids (quercetin and kaempferol) in onion extract play a role in reducing scar formation through inhibition of fibroblast activities. Even though several commercial products are composed of onion extract, the precise molecular mechanisms of onion extract in reduction of scar formation in skin are still largely unknown. In this study we investigated the effect both of onion extract and quercetin on the proliferation of fibroblasts, expression of type I collagen and matrix metalloproteinase-1 (MMP-1). Our data show that proliferation rates of fibroblasts were decreased in a dose-dependent manner of the onion extract and quercetin. The expression of type I collagen was not markedly changed by the onion extract and quercetin. Interestingly, the expression of MMP-1 was markedly increased by both onion extract and quercetin in vitro and in vivo. Thus, our data indicate that onion extract and quercetin play a role in the anti-scar effect in skin through up-regulation of MMP-1 expression, implying this agent is a promising material for reducing scar formation.

Citations

May 28, 2013·Aesthetic Plastic Surgery·Apirag ChuangsuwanichSirichai Kamnerdnakta
Aug 28, 2012·Dermatology Research and Practice·Kumutnart ChanprapaphVasanop Vachiramon
Sep 4, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander NastUNKNOWN German Society of Dermatology
Apr 11, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Qi YeHong Zhang
Dec 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ho-Shin Huang, Ean-Tun Liaw
Mar 3, 2018·International Journal of Molecular Sciences·Ho Jun Lee, Yong Ju Jang
Dec 21, 2019·International Wound Journal·Zhong LingzhiFu Xiaobing
Nov 27, 2015·The Journal of Veterinary Medical Science·Soohyun KimKangmoon Seo

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