PMID: 8976020Dec 1, 1996Paper

Onlay bone graft behaviour after marrow exposure of the recipient rat skull bone

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
P AlberiusO Johnell

Abstract

This study aimed to evaluate the effects on incorporation of onlay grafts after exposure of the marrow of the skull recipient bed. Tibial or femoral uni- and bicortical bone grafts were positioned subperiosteally or submuscularly in the parietal and temporal region, respectively, of 28 adult rats. The recipient bed was ground to remove the external cortical layer and expose the underlying marrow. The outcome was assessed after four, 12, and 20 weeks by routine histology and immunohistochemical labelling for various bone and cartilage proteins. Marrow exposure resulted in an explosive bone formation, prompt graft incorporation, earlier onset of bone remodelling, but also localized resorption at the host bed due to increased vulnerability to pressure. Graft height loss was similar relative to previous observations by us using the same experimental model but without exposure of the marrow. The investigated proteins were identified at various locations and with different temporal sequences; the technique contributed to a diversified appreciation of graft behaviour. The findings emphasize the essential role of the bone marrow constituents to bone graft incorporation.

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Citations

Jan 7, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M GordhO Johnell
Mar 20, 1998·International Journal of Oral and Maxillofacial Surgery·M GordhA Linde
Jan 13, 2000·Journal of Periodontology·Z MajzoubG Cordioli
Jun 18, 2009·Clinical Oral Implants Research·Wagner Fernandes PedrosaLuiz Antonio Salata
Mar 8, 2008·Clinical Oral Implants Research·Paulo E P FariaLuiz A Salata
Jul 11, 2012·Clinical Oral Implants Research·Ana Carolina HawthorneLuiz Antonio Salata
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Sep 1, 1997·Plastic and Reconstructive Surgery·G ZellinA Linde
Jun 8, 1999·Plastic and Reconstructive Surgery·M GordhA Linde
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Jul 18, 2002·Clinical Implant Dentistry and Related Research·Luiz Z SalataKarl-Erik Kahnberg
Jun 5, 2014·The Open Dentistry Journal·Jie Liu, David G Kerns
Aug 18, 1999·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·M Gordh, P Alberius
Apr 22, 2020·The Journal of Oral Implantology·Saurabh Mohandas KamatAshwin Mysore
Aug 12, 1999·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·K WatanabeM Ueda
Sep 1, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ka-Young SeolSung-Chul Lim

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