Online Effects of Transcranial Direct Current Stimulation in Real Time on Human Prefrontal and Striatal Metabolites

Biological Psychiatry
Antoine Hone-BlanchetShirley Fecteau

Abstract

Studies have reported that transcranial direct current stimulation (tDCS) can modulate human behaviors, symptoms, and neural activity; however, the neural effects during stimulation are unknown. Most studies compared the effects of tDCS before and after stimulation. The objective of our study was to measure the neurobiological effect of a single tDCS dose during stimulation. We conducted an online and offline protocol combining tDCS and magnetic resonance spectroscopy (MRS) in 17 healthy participants. We applied anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC) and cathodal tDCS over the right DLPFC for 30 minutes, one of the most common montages used with tDCS. We collected MRS measurements in the left DLPFC and left striatum during tDCS and an additional MRS measurement in the left DLPFC immediately after the end of stimulation. During stimulation, active tDCS, as compared with sham tDCS, elevated prefrontal N-acetylaspartate and striatal glutamate + glutamine but did not induce significant differences in prefrontal or striatal gamma-aminobutyric acid level. Immediately after stimulation, active tDCS, as compared with sham tDCS, did not significantly induce differences in glutamate + glutamine, N-acetylaspartat...Continue Reading

References

Nov 5, 1998·NMR in Biomedicine·M MescherR Gruetter
May 19, 2004·The European Journal of Neuroscience·Michael A NitscheFrithjof Tergau
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael A NitscheWalter Paulus
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R Grant SteenJeffrey A Lieberman
Jan 24, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Prateek C GandigaLeonardo G Cohen
Feb 6, 2007·Progress in Neurobiology·John R MoffettAryan M A Namboodiri
Mar 4, 2008·British Journal of Pharmacology·M W Feltenstein, R E See
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte J StaggHeidi Johansen-Berg
Aug 15, 2009·European Biophysics Journal : EBJ·Marinette van der Graaf
Sep 9, 2010·European Journal of Pain : EJP·Felipe FregniAlvaro Pascual-Leone
Sep 30, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin WilsonAndrew C Peet
Jan 5, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Colleen K LooPerminder Sachdev
Feb 2, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Nicolaas A J Puts, Richard A E Edden
Mar 6, 2012·NeuroImage·Alex FornitoEdward T Bullmore
May 15, 2012·The American Journal of Psychiatry·Jerome BrunelinEmmanuel Poulet
Dec 19, 2012·NeuroImage·Paul G MullinsRichard A E Edden
Mar 21, 2013·Nature Reviews. Neuroscience·Gordon M G Shepherd
Aug 7, 2013·Neuroscience and Biobehavioral Reviews·Jochem M JansenAnna E Goudriaan
Jul 31, 2014·The American Journal of Psychiatry·Chadi G AbdallahGerard Sanacora
Feb 27, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tsuyoshi NihonsugiMasahiko Haruno
Jul 15, 2015·Journal of Magnetic Resonance Imaging : JMRI·Ashley D HarrisRichard A E Edden

❮ Previous
Next ❯

Citations

Jun 12, 2016·Brain Stimulation·Marilyne Joyal, Shirley Fecteau
Jun 8, 2018·Journal of Neuroscience Research·Raphael HirtzOtto W Witte
Jun 12, 2018·Neurodegenerative Disease Management·Hikmat HadoushMuhammed Al-Jarrah
Sep 13, 2019·The American Journal on Addictions·Elena Gomis-VicentAlvaro Pascual-Leone
Oct 11, 2019·Brain Imaging and Behavior·Christoph KrausRupert Lanzenberger
Jul 15, 2018·Journal of Inherited Metabolic Disease·Thomas Reed, Roi Cohen Kadosh
Nov 5, 2019·Brain Stimulation·Amy E BouchardShirley Fecteau
Jun 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·George ZacharopoulosRoi Cohen Kadosh
Sep 5, 2021·Scientific Reports·George ZacharopoulosRoi Cohen Kadosh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.