Online registry for nationwide database of Helicobacter pylori eradication in Korea: Correlation of antibiotic use density with eradication success

Helicobacter
Beom Jin KimJae G Kim

Abstract

The Helicobacter pylori eradication rate has decreased with increasing antibiotic resistance. We conducted a prospective, nationwide, multicenter registry study to monitor the real status of H. pylori eradication therapy and to investigate the association between eradication success and antibiotic use density in Korea. We enrolled 9318 patients undergoing H. pylori eradication therapy from 37 hospitals through "on-line database registry" from October 2010 to July 2015. Demographic data, detection methods, treatment indications, regimens, durations, compliance, adverse events, and eradication results were collected. The use of all commercially available eradication antibiotics was analyzed through the Korean National Health Insurance data of the Health Insurance Review and Assessment Service. The defined daily dose of antibiotics was used to standardize drug use comparisons. Finally, 6738 patients were analyzed. The overall eradication rate of first-line therapy was 71.8%. The eradication success rates were 71.7%, 86.9%, and 74.0% for standard triple therapy for 7 days, quadruple therapy, and concomitant therapy, respectively. The eradication success rate in naive patients was higher than that in those who previously underwent H...Continue Reading

References

Mar 6, 2008·Journal of Gastroenterology and Hepatology·Kwong Ming FockUNKNOWN Asia-Pacific Gastric Cancer Consensus Conference
Apr 25, 2014·Journal of Gastroenterology and Hepatology·Sang Gyun KimUNKNOWN Korean College of Helicobacter and Upper Gastrointestinal Research
Jun 11, 2014·World Journal of Gastroenterology : WJG·Jun Heo, Seong Woo Jeon
Feb 3, 2015·Journal of Gastroenterology and Hepatology·Tiing Leong AngSubbiah Dhamodaran
Apr 15, 2016·Expert Review of Anti-infective Therapy·David Y Graham, Maria Pina Dore
Aug 2, 2016·Journal of Korean Medical Science·Beom Jin KimUNKNOWN Korean College of Helicobacter and Upper Gastrointestinal Research
Nov 2, 2016·Gut·P MalfertheinerUNKNOWN European Helicobacter and Microbiota Study Group and Consensus panel
Nov 3, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ross CampbellJames P Bonaparte
Aug 7, 2017·The Lancet. Gastroenterology & Hepatology·Yu-Ting KuoUNKNOWN Asian Pacific Alliance on Helicobacter and Microbiota

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