Online Sol-gel Capillary Microextraction-Mass Spectrometry (CME-MS) Analysis of Illicit Drugs

Journal of the American Society for Mass Spectrometry
Emre Seyyal, Theresa Evans-Nguyen

Abstract

Providing rapid and sensitive sample cleanup, sol-gel capillary microextraction (CME) is a form of solid phase microextraction (SPME). The capillary format of CME couples easily with mass spectrometry (MS) by employing sol-gel sorbent coatings in inexpensive fused silica capillaries. By leveraging the syringe pump and six-port valve readily available on the commercial MS, we can obviate the need for chromatography for samples as complex as urine in quantitative assays. Two different sol-gel materials were studied as microextraction sorbents: one with a single ligand of octadecyl (C18) and the other with a dual-ligand combination of C18 and phenyl (Phe) groups. The CME-MS method was optimized for flow rate and solvent desorption and studied for overall microextraction performance between the two sorbents studied. We extract illicit drugs including cocaine, heroin, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine, and oxycodone, proving good run-to-run reproducibility (RSD% < 10%) and low detection limits (< 10 ng mL-1). The dual-ligand sorbent demonstrated superior performance due to typical hydrophobic properties of C18 as well as potential π-π interactions of the Phe functionality and the aromatic moiety common ...Continue Reading

References

Jul 18, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·J D Hayes, A Malik
Feb 28, 2002·Analytical Chemistry·Shaun BighamAbdul Malik
Nov 29, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·B K Matuszewski
Apr 18, 2006·Journal of Chromatography. a·Raquel Gomes da Costa Silva, Fabio Augusto
Oct 9, 2007·Analytical Chemistry·Guangming HuangZheng Ouyang
Feb 20, 2010·Rapid Communications in Mass Spectrometry : RCM·Mohammad Reza AlmasianXinrong Zhang
Oct 11, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Joanna RudnickaBogusław Buszewski
Sep 16, 2014·Chemical Communications : Chem Comm·Germán Augusto Gómez-Ríos, Janusz Pawliszyn
Oct 16, 2014·Journal of the American Society for Mass Spectrometry·Joseph LaPointeJason R E Shepard
Mar 21, 2017·Journal of Pharmaceutical and Biomedical Analysis·Marcos TasconJanusz Pawliszyn
Nov 9, 2017·Analytical Chemistry·Nathaly Reyes-GarcésJanusz Pawliszyn

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Citations

Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Feb 3, 2021·Journal of Separation Science·Caroline Fernandes GreccoMaria Eugênia Costa Queiroz
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samir M AhmadJosé M F Nogueira

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