Only skin deep: shared genetic response to the deadly chytrid fungus in susceptible frog species

Molecular Ecology
Erica B RosenblumGordon K Murdoch

Abstract

Amphibian populations around the world are threatened by an emerging infectious pathogen, the chytrid fungus Batrachochytrium dendrobatidis (Bd). How can a fungal skin infection kill such a broad range of amphibian hosts? And do different host species have a similar response to Bd infection? Here, we use a genomics approach to understand the genetic response of multiple susceptible frog species to Bd infection. We characterize the transcriptomes of two closely related endangered frog species (Rana muscosa and Rana sierrae) and analyse whole genome expression profiles from frogs in controlled Bd infection experiments. We integrate the Rana results with a comparable data set from a more distantly related susceptible species (Silurana tropicalis). We demonstrate that Bd-infected frogs show massive disruption of skin function and show no evidence of a robust immune response. The genetic response to infection is shared across the focal susceptible species, suggesting a common effect of Bd on susceptible frogs.

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Citations

Sep 28, 2013·PloS One·Liang QiaoZhaobin Song
Apr 30, 2013·Emerging Infectious Diseases·Evan A Eskew, Brian D Todd
May 28, 2013·Diseases of Aquatic Organisms·Steven M WhitfieldJacob L Kerby
Jun 12, 2014·Integrative and Comparative Biology·Ana V LongoKelly R Zamudio
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Erica Bree RosenblumJason E Stajich
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Jul 24, 2020·Molecular Ecology·Anna E SavageRobert C Fleischer
Aug 4, 2020·Molecular Ecology·Alexander Shepack, Alessandro Catenazzi

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