Onset and duration of action of formoterol and tiotropium in patients with moderate to severe COPD

Respiration; International Review of Thoracic Diseases
Kai RichterH Magnussen

Abstract

Chronic obstructive pulmonary disease (COPD) management guidelines recommend regular treatment with one or more long-acting bronchodilators for patients with moderate to severe COPD. To compare the onset and duration of action of formoterol and tiotropium in patients with COPD. This randomized, multicentre, open-label crossover study in 38 patients with COPD (mean age 64 years; mean FEV(1) 55% predicted) assessed the effect of 7 days of treatment with formoterol (12 microg b.i.d. via Foradil Aerolizer) vs. tiotropium (18 microg o.d. via Spiriva HandiHaler) on lung function measured over a period of 12 h after the first dose on day 1 and the last dose on day 8. The primary efficacy variable, FEV(1)-AUC during the first 2 h post-dose (FEV(1)-AUC(10-120 min)), was significantly higher for formoterol compared with tiotropium, with between-treatment differences of 124 ml (p = 0.016) after the first dose and 80 ml (p = 0.036) after 7 days' treatment in favour of formoterol. FEV(1) measured 12 h after inhalation did not differ statistically significantly between treatments. Adverse events occurred in 2 (5%) patients after treatment with formoterol and in 5 (12%) patients after treatment with tiotropium. This study demonstrates faster ...Continue Reading

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Citations

Nov 23, 2007·Respiration; International Review of Thoracic Diseases·Frank J VisserYvonne F Heijdra
Aug 18, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Nicholas J Gross, James F Donohue
Aug 5, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Jutta Beier, Kai M Beeh
Jun 1, 2008·Expert Review of Respiratory Medicine·Yaoli WangXiangdong Wang
Feb 21, 2009·COPD·Donald P TashkinSantosh T Varghese
Jan 19, 2010·Pulmonary Pharmacology & Therapeutics·Peter J BarnesDavid Lawrence
Aug 28, 2007·Clinics in Chest Medicine·Nicola A Hanania, Amir Sharafkhaneh
Aug 9, 2008·Respiratory Medicine·Mario CazzolaStephen Rennard
Jun 13, 2014·Current Opinion in Pharmacology·Nastasia V WasilewskiJohn T Fisher
Jan 18, 2012·Therapeutic Advances in Respiratory Disease·Roberto Walter Dal NegroFrancesco Menegoni
Jul 22, 2014·The Cochrane Database of Systematic Reviews·Charlotta KarnerPhillippa Poole
Dec 5, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Donald P Tashkin

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