Onset and duration of action of rocuronium--from tracheal intubation, through intense block to complete recovery

Acta Anaesthesiologica Scandinavica
P SchultzL T Skovgaard

Abstract

The primary objective of this study was to establish the relation between the post tetanic count (PTC) and the time to reappearance of the first response (T1) in train-of-four (TOF) nerve stimulation following rocuronium 0.6 mg/kg, 0.9 mg/kg, and 1.2 mg/kg. The secondary objective was to evaluate the intubation conditions after 1 min. One hundred and eight patients were randomised to one of three doses of rocuronium: 0.6, 0.9 or 1.2 mg/kg. Tracheal intubation was performed at 60 s by a blinded investigator. During propofol, fentanyl, midazolam anaesthesia the neuromuscular block was monitored by mechanography using TOF stimulation every 12 s. At 6 min intervals, a tetanic stimulation (50 Hz) was applied for 5 s preceded and followed by a 30 s period of 1 Hz stimulation until the reappearance of T1. There was a significant difference in recovery following the high dose and the two lower doses. The relation between time (min) to reappearance of T1 (t) and PTC can be expressed as follows: t(0.6 and 0.9 mg/kg)(min)=18.8-6.46 PTC and t(1.2 mg/kg)(min)=26.1-9.12 PCT. T1 was seen at a mean PTC level of 8 or 9 in all three groups. The intubation conditions were graded as excellent or good in all patients except in two patients followin...Continue Reading

References

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Citations

Apr 15, 2011·Obesity Surgery·Tomoki NishiyamaKeiko Koishi
Sep 26, 2003·Journal of Clinical Anesthesia·Nur BaykaraKamil Toker
Oct 5, 2006·Current Opinion in Anaesthesiology·J Viby-Mogensen
Jul 11, 2007·Current Opinion in Anaesthesiology·Aaron M Fields, Nalini Vadivelu
Jul 24, 2004·Anesthesia and Analgesia·TaeHyung HanJ A Jeevendra Martyn
Aug 20, 2009·Anesthesia and Analgesia·Christian S MeyhoffLars S Rasmussen
Apr 29, 2009·Veterinary Anaesthesia and Analgesia·Farshid Sarrafzadeh-Rezaei, R Eddie Clutton
Apr 29, 2009·Acta Anaesthesiologica Scandinavica·A C Morales MartínC Muriel Villoria
Apr 13, 2011·Acta Anaesthesiologica Scandinavica·R M WilliamsonP Barclay
Feb 28, 2016·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·David HakimLouis-Philippe Fortier
Dec 5, 2017·Anesthesia and Analgesia·Mohamed NaguibKen B Johnson
Jun 29, 2018·Anesthesia Progress·Stephen GoetzBryant Cornelius
Jan 28, 2015·Anesthesia and Analgesia·Aaron F Kopman, Mohamed Naguib
Sep 27, 2014·European Journal of Anaesthesiology·Michele Carron
Aug 14, 2019·Biological & Pharmaceutical Bulletin·Miki MatsuiShinichi Yamamoto
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Amir AbrishamiFrances Chung
Apr 17, 2020·Acta Anaesthesiologica Scandinavica·Jakob L D ThomsenDoris Østergaard
Oct 27, 2017·Anesthesiology·Sorin J Brull, Mohamed Naguib

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