Onset and duration of beta-adrenergic receptor blockade following single oral dose acebutolol hydrochloride (Sectral)

British Journal of Clinical Pharmacology
R D Watson, W A Littler

Abstract

1. The onset and duration of action of once daily acebutolol (400 mg) on resting and exercise heart rate and blood pressure were studied in normal subjects in a double-blind, cross-over trial against placebo. Subjects were studied 1.5, 3, 8 and 24 h after the first dose and 24 h after the fifth dose. 2. Resting and exercise heart rate and blood pressure were significantly reduced within 90 min of the first dose. 3. A significant reduction in these variables persisted throughout 24 h after the fifth daily dose. However, at 24 h the effects were considerably attenuated, the falls in resting and exercise systolic blood pressure being only 5%. 4. A linear relationship was noted between log serum drug level and percentage reduction of exercise heart rate.

References

May 1, 1985·American Heart Journal·G De BonoA J Summers
May 1, 1988·Journal of Clinical Pharmacology·I L PiñaD J Weidler
Feb 1, 1986·International Journal of Cardiology·P A Crean, D O Williams
Feb 1, 1980·British Journal of Clinical Pharmacology·R D WatsonW A Littler

Citations

Feb 1, 1975·British Journal of Clinical Pharmacology·C F George
Oct 1, 1977·British Journal of Clinical Pharmacology·T A JeffersN P Barker
Feb 1, 1975·British Journal of Clinical Pharmacology·M F Cuthbert, R F Collins

Related Concepts

Rhotral
Research Subject
Diastolic Blood Pressure
Cross-Over Studies
Acebutolol Hydrochloride
Heart
Blood Pressure
Acebutolol
Systolic Pressure
Serum

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