Onset and rate of striatal atrophy in preclinical Huntington disease

Neurology
E H AylwardC A Ross

Abstract

Huntington disease (HD) is characterized by striatal atrophy that begins long before the onset of motor symptoms. To determine when striatal atrophy begins, the extent and rate of atrophy before diagnosis of motor symptoms, and whether striatal atrophy can predict when symptom onset will occur. Caudate and putamen volumes were measured on MRI scans of 19 preclinical subjects with the HD gene expansion who were very far (9 to 20 years) from estimated onset, and on serial scans from 17 preclinical subjects, six of whom were diagnosed with HD within 5 years after the initial scan. Striatal volumes were significantly smaller for the subjects who were very far from estimated onset than for age-matched control subjects. Statistical models fit to the longitudinal data suggest that rate of caudate atrophy becomes significant when subjects are approximately 11 years from estimated onset and rate of putamen atrophy becomes significant approximately 9 years prior to onset. In the six incident cases, caudate and putamen were approximately one-third to one-half of normal volume at diagnosis, and caudate volume alone was able to predict with 100% accuracy those subjects who would be diagnosed within 2 years of imaging. Striatal atrophy begin...Continue Reading

Citations

Jan 11, 2008·Experimental Brain Research·A PeltschD P Munoz
Apr 25, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Andrea CiarmielloFerdinando Squitieri
Jan 22, 2009·Journal of Neurology·Caroline K JurgensRaymund A C Roos
Oct 14, 2009·Journal of Neurology·Caroline K JurgensRaymund A C Roos
Oct 12, 2010·Journal of Neurology·Simon J A van den BogaardUNKNOWN TRACK-HD Investigator Group
Mar 1, 2009·Brain Imaging and Behavior·Vincent A MagnottaJane S Paulsen
Sep 1, 2005·Current Neurology and Neuroscience Reports·Julie C Stout, Shannon A Johnson
Aug 24, 2011·Current Neurology and Neuroscience Reports·Jane S Paulsen
Aug 19, 2011·The Cerebellum·Brian C JungSarah H Ying
Jan 24, 2007·Lancet·Francis O Walker
Apr 21, 2007·Journal of the International Neuropsychological Society : JINS·Sean C HintonStephen M Rao
Aug 19, 2007·Journal of the International Neuropsychological Society : JINS·Janice L ZimbelmanStephen M Rao
Jul 29, 2009·Journal of the International Neuropsychological Society : JINS·Eva PirogovskyPaul E Gilbert
Feb 9, 2011·Journal of Clinical and Experimental Neuropsychology·Justin J F O'RourkeJane S Paulsen
Dec 4, 2012·Journal of Clinical and Experimental Neuropsychology·Laura MickesJody Corey-Bloom
Dec 15, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Justin J F O'RourkeLeigh J Beglinger
Jan 19, 2012·Brain : a Journal of Neurology·Richard GrondinWilliam F Kaemmerer
Nov 26, 2009·Human Molecular Genetics·Gelareh MazareiBlair R Leavitt
Mar 2, 2010·Human Molecular Genetics·Claudia RoseDavid C Rubinsztein
Sep 21, 2007·Journal of Computer Assisted Tomography·Cinzia GavazziMario Mascalchi
Dec 13, 2006·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Maree FarrowNellie Georgiou-Karistianis
Dec 20, 2007·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Julie C StoutTatiana Foroud
Jan 14, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J C H van OostromK L Leenders
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·C M KippsE A McCusker
Dec 21, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Camille L JulienDavid Craufurd
Dec 22, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·J S PaulsenUNKNOWN Predict-HD Investigators and Coordinators of the Huntington Study Group
Sep 4, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Jason RuppTatiana Foroud
Oct 5, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Elizabeth H AylwardUNKNOWN PREDICT-HD Investigators and Coordinators of Huntington Study Group
Aug 30, 2013·The Journal of Clinical Investigation·Chris C TangDavid Eidelberg
Feb 7, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Jason BrandtChristopher A Ross
May 14, 2010·The Journal of Neuropsychiatry and Clinical Neurosciences·Kevin DuffUNKNOWN Predict-HD Investigators of the Huntington Study Group
Nov 3, 2010·PLoS Currents·Aimee HunterAndrew Leuchter
Dec 7, 2007·PloS One·Christian BesteMichael Falkenstein
Aug 16, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·D S Adnan MajidAdam R Aron
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Eckert, David Eidelberg
Nov 20, 2013·International Journal of Molecular Sciences·Edward C Lauterbach
Dec 20, 2013·International Journal of Molecular Sciences·Jie LiHossein A Ghanbari
Nov 18, 2008·The Journal of Clinical Psychiatry·Leigh J BeglingerJulie C Stout
Jun 26, 2014·Brain Sciences·Andrew T CraneGary L Dunbar
Jan 1, 2010·Future Neurology·Jane S Paulsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.