Onset and Remission of Psychosis in Parkinson's Disease: Pharmacologic and Motoric Markers.

Movement Disorders Clinical Practice
Jared T HinkleGregory M Pontone

Abstract

Psychosis is among the most disabling complications of Parkinson's disease (PD). The chronicity of PD psychosis remains understudied and the relative importance of dopaminergic therapy versus the disease process itself in engendering psychosis remains unclear. To examine pharmacologic and motoric correlates of PD psychosis onset and remission in a longitudinally monitored PD cohort. We analyzed data from 165 participants enrolled in a longitudinal PD study through the Morris K. Udall Parkinson's Disease Research Center of Excellence at Johns Hopkins University. Evaluations included formal psychiatric assessment and were conducted at two-year intervals. Regression with generalized estimated equations (GEE) was used to produce unadjusted and adjusted estimates for time-varying longitudinal associations between psychosis and putative risk factors. Sixty-two participants (37.6%) were diagnosed with psychosis during at least one evaluation. Of forty-nine participants with psychosis followed over multiple evaluations, 13 (26.5%) demonstrated remission despite significant Hoehn & Yahr stage increase (p=0.009); two of these cases later relapsed. Multivariable regression with GEE identified dementia diagnosis, akinesia-rigidity, anticho...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Feb 1, 1992·The American Journal of Psychiatry·D V JesteL J Thal
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jan 29, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·D V Jeste, S I Finkel
Sep 1, 2000·Journal of the American Geriatrics Society·D AarslandK Laake
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·S HolroydG F Wooten
Dec 5, 2003·Journal of Geriatric Psychiatry and Neurology·Nicholas HoehJoel Streim
Jun 15, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Gail A KangBeate Ritz
Jan 13, 2006·Neurology·Gilles FénelonAxel Karenberg
Apr 26, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Guido AlvesDag Aarsland
May 10, 2006·Archives of Neurology·Christopher G GoetzGlenn T Stebbins
Jul 23, 2008·Practical Neurology·Werner Poewe
Nov 4, 2008·Parkinsonism & Related Disorders·J S A M ReijndersA F G Leentjens
Sep 11, 2009·Journal of the Neurological Sciences·Gilles Fénelon, Guido Alves
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Dec 29, 2011·Dementia and Geriatric Cognitive Disorders Extra·Joseph J Locascio, Alireza Atri
Mar 22, 2016·JAMA Neurology·Daniel WeintraubHelen C Kales
Jul 9, 2016·Progress in Neurobiology·Philippe De DeurwaerdèreMark J Millan
Aug 23, 2016·Annals of Clinical and Translational Neurology·Vikas Kotagal
Nov 3, 2016·Current Opinion in Neurology·Rainer von Coelln, Lisa M Shulman
Feb 14, 2017·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Daniel ErskineAhmad A Khundakar
Mar 14, 2017·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jared T Hinkle, Gregory M Pontone

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Citations

Jun 5, 2019·Expert Review of Clinical Pharmacology·Kelly E LyonsStuart Isaacson
May 7, 2020·The Journal of Neuropsychiatry and Clinical Neurosciences·Alice PowellSimon J G Lewis
Apr 18, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ryo IketaniHiroshi Yamada

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