PMID: 9417133Feb 14, 1998Paper

Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation

The Journal of General Physiology
P D CalvertV Y Arshavsky

Abstract

Light adaptation in vertebrate photoreceptors is thought to be mediated through a number of biochemical feedback reactions that reduce the sensitivity of the photoreceptor and accelerate the kinetics of the photoresponse. Ca2+ plays a major role in this process by regulating several components of the phototransduction cascade. Guanylate cyclase and rhodopsin kinase are suggested to be the major sites regulated by Ca2+. Recently, it was proposed that cGMP may be another messenger of light adaptation since it is able to regulate the rate of transducin GTPase and thus the lifetime of activated cGMP phosphodiesterase. Here we report measurements of the rates at which the changes in Ca2+ and cGMP are followed by the changes in the rates of corresponding enzymatic reactions in frog rod outer segments. Our data indicate that there is a temporal hierarchy among reactions that underlie light adaptation. Guanylate cyclase activity and rhodopsin phosphorylation respond to changes in Ca2+ very rapidly, on a subsecond time scale. This enables them to accelerate the falling phase of the flash response and to modulate flash sensitivity during continuous illumination. To the contrary, the acceleration of transducin GTPase, even after significa...Continue Reading

References

Sep 1, 1992·The Journal of Physiology·L LagnadoP A McNaughton
Jun 1, 1992·Neuron·L Lagnado, D Baylor
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Zozulya, L Stryer
Feb 14, 1992·Analytical Biochemistry·S P Brooks, K B Storey
Sep 1, 1991·The Journal of General Physiology·L Lagnado, P A McNaughton
Jan 1, 1989·Annual Review of Neuroscience·K W Yau, D A Baylor
Sep 1, 1988·The Journal of Physiology·A L Hodgkin, B J Nunn
Feb 1, 1989·European Journal of Biochemistry·M Chabre, P Deterre
Sep 1, 1971·The Journal of General Physiology·D BowndsW Robinson
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A YamazakiM W Bitensky
Mar 22, 1994·Biochemistry·W A GorczycaK Palczewski
Oct 15, 1994·The Journal of Physiology·M C Cornwall, G L Fain
Jul 28, 1995·The Journal of Biological Chemistry·C K ChenJ B Hurley
Mar 3, 1995·The Journal of Biological Chemistry·J B AmesL Stryer
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·W A GorczycaK Palczewski
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H CoteV Y Arshavsky
Aug 1, 1993·Current Opinion in Neurobiology·Y Koutalos, K W Yau
Nov 1, 1995·The Journal of General Physiology·Y KoutalosK W Yau
Nov 1, 1995·The Journal of General Physiology·Y KoutalosK W Yau
Jan 1, 1996·Journal of Neurophysiology·J P YoungerW G Owen
Sep 1, 1996·Journal of Neurophysiology·S T McCarthyW G Owen
Oct 25, 1996·The Journal of Biological Chemistry·J G Aparicio, M L Applebury

❮ Previous
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Citations

Aug 17, 1999·Current Opinion in Neurobiology·E N PughT D Lamb
Apr 28, 2006·Visual Neuroscience·Bang V Bui, Brad Fortune
Nov 15, 2011·The Journal of Biological Chemistry·Vadim Y Arshavsky, Marie E Burns
Feb 14, 1998·The Journal of General Physiology·D Tranchina
Feb 14, 1998·The Journal of General Physiology·S NikonovE N Pugh
Oct 5, 2001·The Journal of General Physiology·H R MatthewsR K Crouch
Jan 30, 2002·The Journal of General Physiology·James B Hurley
Jan 30, 2002·The Journal of General Physiology·Peter D CalvertClint L Makino
Oct 27, 2004·The Journal of General Physiology·Eduardo SolessioBarry E Knox
Oct 29, 2008·The Journal of General Physiology·Luba A AstakhovaVictor I Govardovskii
Mar 27, 2007·Neural Computation·H P Snippe, J H van Hateren
Jun 3, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander V KolesnikovOleg G Kisselev
Oct 9, 2002·Neuron·Marie E BurnsDenis A Baylor
Dec 14, 2001·The Journal of Biological Chemistry·Michael J PagliaRick H Cote
Jun 18, 2005·The Journal of Biological Chemistry·Katherine J StrisselVadim Y Arshavsky
Jan 12, 2001·Physiological Reviews·G L FainY Koutalos
May 13, 2021·The Journal of Physiology·Annia AbtoutJürgen Reingruber

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