Onset of lupus like syndrome in patients with spondyloarthritis treated with anti-TNF-α.

International Archives of Medicine
Eduardo Puertas-AbreuGRUPO GRUVES: grupo Venezolano para el Estudio de las Espondiloartritis

Abstract

The anti-TNFα therapy has been since its approval by the FDA, along with nonsteroidal antiinflammatory drugs (NSAIDs), one of the most important therapies for control of spondyloarthritis (SpA). The onset of Lupus Like Syndrome (LLS) has been described in patients with rheumatoid arthritis (RA) treated with anti-TNFα therapy but there is little literature on the occurrence of this entity in patients with SpA. We studied 57 patients with SpA who received more than 1 year of anti-TNFα therapy (infliximab, adalimumab or etanercept). Patients were analyzed for the development of LLS, in addition to measuring ANA levels ≥ 1:160 and Anti-dsDNA (measured by IIF). In total, 7.01% of patients treated with anti-TNFα had titers of ANA ≥ 1:160, whereas 3.5% of patients had serum levels of dsDNA. However, only one patient (1.75%; n = 1) experienced clinical symptoms of LLS; this was a female patient with a history of psoriatic arthritis. The presence of LLS secondary to anti-TNFα therapy in patients with SpA is observed less frequently compared with patients with RA. LLS was only detected in a patient with a history of psoriasis since youth, who developed psoriatic arthritis after 27 years of age and had received anti-TNFα therapy for > 2 y...Continue Reading

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Citations

Aug 12, 2014·Gastroenterology Clinics of North America·Joseph D Feuerstein, Adam S Cheifetz
Oct 18, 2013·Immunological Investigations·Maria Roseli Monteiro CalladoJosé Rubens Costa Lima
Apr 10, 2013·Orvosi hetilap·Nóra GyöngyösiNorbert Wikonkál
Aug 5, 2017·The British Journal of Dermatology·S E MomenC H Smith
Jul 24, 2013·Current Opinion in Allergy and Clinical Immunology·Valérie Gouilleux-GruartAlain Fischer
Nov 2, 2012·Current Opinion in Rheumatology·Roberto Perez-AlvarezUNKNOWN BIOGEAS study group
Mar 31, 2021·Clinical Rheumatology·Aliki I VenetsanopoulouParaskevi V Voulgari

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