Onset of major depression associated with acute coronary syndromes: relationship of onset, major depressive disorder history, and episode severity to sertraline benefit

Archives of General Psychiatry
Alexander H GlassmanJ Robert Swenson

Abstract

Depression observed following acute coronary syndrome (ACS) is common and associated with an increased risk of death. The Sertraline Antidepressant Heart Attack Trial (SADHART) tested the safety and efficacy of a selective serotonin reuptake inhibitor in this population. No evidence of harm was seen, and sertraline hydrochloride had an overall beneficial effect on mood that occurred primarily in patients with a history of episodes of major depressive disorder (MDD). To determine how frequently the MDD began before ACS and whether onset of the current MDD episode before or after the ACS event influenced response to sertraline. A randomized, double-blind, placebo-controlled treatment of 369 patients with ACS and MDD was conducted in 40 outpatient clinics in 10 countries between April 1, 1997, and April 30, 2001. Diagnosis of MDD, number of previous episodes of depression, and episode onset before or after hospitalization were established using the Diagnostic Interview Schedule. Treatment response was measured with the Clinical Global Impression-Improvement scale. Fifty-three percent of MDD episodes began before hospitalization for the index episode of ACS (for 197 of 369 patients), and 94% of the MDD episodes began more than 30 d...Continue Reading

Citations

Aug 10, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·S PiniA Balbarini
Dec 24, 2009·Cardiovascular Psychiatry and Neurology·Jane Pei-Chen ChangKuan-Pin Su
Feb 27, 2013·Molecular Psychiatry·W D TaylorG S Alexopoulos
Apr 12, 2011·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Lynn V Doering, Jo-Ann Eastwood
Mar 7, 2012·Medical Hypotheses·Dennis J McCarthyGerard Sanacora
Apr 2, 2011·Journal of the American Geriatrics Society·J Craig Nelson, Davangere P Devanand
Feb 26, 2010·Pharmacotherapy·Kelly M SummersKristin Watson
May 9, 2013·Cardiovascular Psychiatry and Neurology·Jeff C HuffmanJames L Januzzi
May 26, 2016·Current Psychiatry Reports·Gary J KennedyManuel Fishman
Oct 21, 2011·American Journal of Hypertension·Ingrid M M van HaelstToine C G Egberts
Mar 23, 2007·Depression and Anxiety·Diane StrachowskiC Barr Taylor
Jun 8, 2011·Psychotherapy and Psychosomatics·Johan Ormel, Peter de Jonge
May 16, 2018·Acta Psychiatrica Scandinavica·A KoyanagiCarsten Hjorthøj
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Harald BaumeisterJürgen Bengel
Apr 6, 2011·Cardiology in Review·Christopher M Celano, Jeff C Huffman
Oct 24, 2007·Heart Failure Reviews·Peter A Shapiro
Jan 29, 2008·Current Psychiatry Reports·Emily D Williams, Andrew Steptoe
Jul 26, 2008·Current Psychiatry Reports·Meera NarasimhanAshley Blackmon Jones
Apr 29, 2010·Current Psychiatry Reports·Yelizaveta SherJosé R Maldonado
Oct 12, 2012·Der Nervenarzt·F Lederbogen, A Ströhle
Feb 27, 2014·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Adrienne O'NeilUNKNOWN MoodCare Investigator Team
Jul 1, 2020·Scandinavian Journal of Gastroenterology·Erik LexnePer-Olof Nylander
Aug 19, 2015·Current Cardiology Reports·Peter A Shapiro
Aug 7, 2019·Translational Psychiatry·George S Alexopoulos
Feb 18, 2020·British Journal of Health Psychology·Mercedes Arrebola-MorenoRocio Garcia-Retamero
Feb 26, 2010·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Yekta DowlatiKrista L Lanctôt
Oct 30, 2018·Journal of the American Heart Association·Chowdhury S AbdullahMd Shenuarin Bhuiyan
Jan 1, 2013·Journal of Psychosomatic Research·Peter A Shapiro
Jul 27, 2021·Frontiers in Physiology·Richa AishwaryaMd Shenuarin Bhuiyan
Jul 14, 2010·Journal of Psychosomatic Research·Rebecca A GaryAndrew L Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.