Onset of opportunity to use cannabis and progression from opportunity to dependence: Are influences consistent across transitions?

Drug and Alcohol Dependence
Lindsey A HinesMichael T Lynskey

Abstract

There is a developing body of research looking at cannabis use opportunity, but little research examining timing of opportunity to use cannabis. Identify factors associated with (1) earlier opportunity to use cannabis and (2) faster progression from opportunity to cannabis dependence. Cross-sectional study of 3824 Australian twins and siblings, measuring age of onset of cannabis use opportunity and DSM-IV cannabis dependence. Survival analysis identified factors associated with faster progression to opportunity or dependence. Factors associated with both speed of progression to opportunity and dependence were conduct disorder (opportunity HR 5.57, 95%CI 1.52-20.47; dependence HR 2.49, 95%CI 1.91-3.25), parental drug problems (opportunity HR 7.29, 95%CI 1.74-30.62; dependence HR 3.30, 95%CI 1.63-6.69), weekly tobacco use (opportunity HR 8.57, 95%CI 3.93-18.68; dependence HR 2.76, 95% CI 2.10-3.64), and female gender (opportunity HR 0.69, 95%CI 0.64-0.75; dependence HR 0.44, 95%CI 0.34-0.55). Frequent childhood religious attendance (HR 0.74, 95%CI 0.68-0.80), parental conflict (HR 1.09, 95%CI 1.00-1.18), parental alcohol problems (HR 1.19, 95%CI 1.08-1.30) and childhood sexual abuse (HR 1.17, 95%CI 1.01-1.34) were uniquely associ...Continue Reading

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Aug 25, 2015·Current Addiction Reports·Lindsey A HinesMichael Lynskey

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Citations

Apr 8, 2016·Nature Reviews. Neuroscience·H Valerie CurranLoren H Parsons
Jan 22, 2020·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Ofir Turel
May 13, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Matthew HickmanSuzie H Gage
Jun 11, 2017·Addiction·Jasmina Burdzovic Andreas, Anne Line Bretteville-Jensen
Mar 27, 2018·Addiction·Michael T Lynskey, Arpana Agrawal
Sep 26, 2019·Journal of Attention Disorders·Nieves Martínez-LunaJosep Antoni Ramos-Quiroga
Jun 15, 2021·Frontiers in Psychiatry·Víctor De la Peña-ArteagaLindsey A Hines

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