PMID: 3021300Sep 1, 1986Paper

Onset of pancuronium and d-tubocurarine blockade with priming

Canadian Anaesthetists' Society Journal
F DonatiD R Bevan


The synergistic effect of pancuronium bromide (PCB) and d-tubocurarine (DTC) on the onset time of neuromuscular blockade was tested in 108 ASA physical status I and II adults anaesthetized with thiopentone, nitrous oxide and halothane. Either saline or a small (priming) dose (DTC, 0.04 mg X kg-1, or PCB, 0.007 mg X kg-1) was administered 3 min before a paralyzing dose of either DTC or PCB. The total dose of relaxant was equivalent to DTC, 0.4 mg X kg-1, or PCB, 0.07 mg X kg-1. Neuromuscular activity was measured using train-of-four stimulation applied every 12 s. Time to 50 per cent first twitch blockade was 63 +/- 4.6 s (mean +/- SEM) with DTC and 88 +/- 5.2 s with PCB (p less than 0.002). Times to 90 per cent blockade were not different between the two drugs (161 +/- 20 s and 141 +/- 21 s respectively). Priming a DTC blockade with either DTC or PCB or priming a PCB blockade with PCB produced an acceleration of less than 10 s at all levels of blockade. Compared with PCB alone, priming PCB blockade with DTC reduced the time to 50 per cent blockade to 71 +/- 4.5 s (p less than 0.02) and to 90 per cent blockade to 111 +/- 8 s (p less than 0.05). Priming did not affect the duration of action significantly, except in the case of PC...Continue Reading


Apr 1, 1978·British Journal of Anaesthesia·C L Blackburn, M Morgan
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Nov 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C E SmithD R Bevan
Mar 1, 1994·Journal of Clinical Anesthesia·R V MiguelD L Dombrowski
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Related Concepts

Anesthesia Procedures
Synaptic Transmission
Neuromuscular Blocking Agents
Pancuronium Curamed
Tubocurarine Chloride

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