PMID: 11906908Mar 22, 2002Paper

Onset of steroidogenic enzyme gene expression during ovarian follicular development in sheep

Biology of Reproduction
Kathleen A LoganKenneth P McNatty

Abstract

Steroidogenesis is a major function of the developing follicle. However, little is known about the stage of onset of steroid regulatory proteins during follicular development in sheep. In this study, several steroidogenic enzymes were studied by immunohistochemistry and/or in situ hybridization; cytochrome P450 side chain cleavage (P450(scc)), cytochrome P450 17alpha-hydroxylase (17alphaOH), 3beta-hydroxysteroid dehydrogenase (3beta-HSD), cytochrome P450 aromatase (P450(arom)), steroidogenic factor 1 (SF-1), steroidogenic acute regulatory protein (StAR), and LH receptor (LH-R). To define the stages of follicular growth, ovarian maps were drawn from serial sections of ovine ovaries, and follicles were located and classified at specific stages of growth based on morphological criteria. In this way, the precise onset of gene expression with respect to stages of follicular growth for all these proteins could be observed. The key findings were that ovine oocytes express StAR mRNA at all stages of follicular development and that granulosa cells in follicle types 1-3 express 3beta-HSD and SF-1. Furthermore, the onset of expression in theca cells of StAR, P450(scc), 17alphaOH, 3beta-HSD, and LH-R occurred in large type 4 follicles just...Continue Reading

References

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Citations

Jun 15, 2013·Journal of Developmental Origins of Health and Disease·V PadmanabhanA Veiga-Lopez
Sep 13, 2013·Molecular Human Reproduction·M Lebbe, T K Woodruff
Feb 15, 2013·PloS One·Katja HummitzschRaymond J Rodgers
Jun 22, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Matthew CotterillHelen M Picton
Mar 31, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·R Braw-Tal, Z Roth
Jul 22, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Jennifer L JuengelKenneth P McNatty
Jul 16, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·J M Young, A S McNeilly
Jan 7, 2016·The Journal of Endocrinology·Anne R O'ConnellJennifer L Juengel
Feb 21, 2006·Gene Expression Patterns : GEP·Cécile NotarnicolaBrigitte Boizet-Bonhoure
Oct 21, 2009·Acta Veterinaria Scandinavica·Michael A SteeleBrian W McBride
Feb 13, 2020·Reproductive Sciences·Muraly PuttabyatappaVasantha Padmanabhan
Dec 17, 2015·Endocrinology·Amanda L MerenessMichael T Sellix
Jan 11, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Anthony EstienneDanielle Monniaux
Dec 19, 2019·Frontiers in Endocrinology·Mohamed A Abedel-MajedAndrea S Cupp
Dec 20, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Monica D HartantiRaymond J Rodgers

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