Onset of the preovulatory luteinizing hormone surge: diurnal timing and critical follicular prerequisites

Fertility and Sterility
D J CahillM G Hull

Abstract

To determine the diurnal variation in the onset of the preovulatory LH surge in women. Prospective open cohort study. University hospital research program. Thirty-five women with infertility resulting from tubal damage that was associated with minor endometriosis or with infertility of prolonged unexplained etiology. Women underwent transvaginal ultrasonography and serum E2 estimation daily during monitored cycles before unstimulated natural cycle IVF: exogenous gonadotropins were not administered. Serum E2 concentration, follicle diameter, and endometrial thickness. Of 169 cycles. 155 progressed to an ovulatory LH surge, of which 146 occurred within 8 hours of assessment of the outcome measures. The relationship between follicle diameter and E2 was weak, but an abnormal value for one always was countered by a normal value for the other. Most women begin the preovulatory LH surge between midnight and 8:00 A.M., but with no particular variation by day of the week. The relationship between follicle size and serum E2 is not sufficiently strong to predict the LH surge confidently on the basis of only one variable, but the LH surge is unlikely to occur before either the follicle diameter has reached 15 mm and/or the serum E2 level h...Continue Reading

References

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Citations

Feb 6, 2013·Progress in Biophysics and Molecular Biology·M J BodenD J Kennaway
Nov 19, 2010·Biology of Reproduction·Megan M MahoneyTheresa M Lee
Mar 13, 2010·International Journal of Endocrinology·Megan M Mahoney
May 8, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Mark A Cervinski, Ann M Gronowski
Aug 31, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Michael J Boden, David J Kennaway
Nov 30, 2013·Frontiers in Neuroendocrinology·Matthew Bailey, Rae Silver
Jul 26, 2015·Annual Review of Physiology·Tracy A BedrosianRandy J Nelson
Oct 18, 2011·Gynécologie, obstétrique & fertilité·C JaminUNKNOWN Groupe de réflexion « oublis de pilule »
Jun 12, 2013·Chronobiology International·Elena ToffolTimo Partonen
Nov 16, 2010·General and Comparative Endocrinology·Janet L CrawfordDouglas C Eckery
Dec 5, 2014·Biology of Reproduction·Yanchang WeiQing-Yuan Sun
Nov 26, 2018·The European Journal of Neuroscience·Valérie Simonneaux
Dec 1, 2004·Human Reproduction Update·David J Kennaway
Mar 19, 2002·Human Fertility : Journal of the British Fertility Society·Johanna Trinder, David J Cahill
Nov 14, 2006·Human Reproduction Update·I M W EbischR P M Steegers-Theunissen
Feb 27, 2020·Endocrinology·Thibault BahougneValérie Simonneaux
Jan 10, 2018·Bioengineering & Translational Medicine·Hsiu-Wei SuChao-Min Cheng
Mar 27, 2020·Frontiers in Endocrinology·James M Olcese
Feb 25, 2006·Hormones and Behavior·Lance J Kriegsfeld, Rae Silver

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