PMID: 7334374Dec 1, 1981Paper

Ontogenesis of muscarinic receptors and acetylcholinesterase activity in various areas of chick brain

Journal of Neurochemistry
D JerusalinskyE De Robertis

Abstract

Muscarinic receptors, labeled with [3H]quinuclidinyl benzylate ([3H]QNB), and acetylcholinesterase activity were studied in five areas of the developing chick brain: (1) hyperstriatum and neostriatum, (2) paleostriatum, (3) optic lobes, (4) mesodiencephalon and (5) cerebellum. The protein content of these areas, expressed as mg/g tissue and total protein, was determined between day -10 and adulthood. Differences in both determinations were observed among the areas. The binding of [3H]QNB was expressed as density (fmol/mg protein) and total number of receptors (fmol/total protein) in the area. Considerable variations were observed among the areas. The cerebellum showed the lowest receptor density and a large decrease in density and total number of receptors in the adult, which may reflect a change in neuronal population. Acetylcholinesterase, in certain areas, accompanied the changes in receptor concentration, but the timing and rate of increase had special features in each case. The most striking one was the cerebellum, in which the enzyme increased steadily postnatally, while the muscarinic receptors dropped to very low values.

References

Dec 3, 1979·Life Sciences·J Lehmann, H C Fibiger
Aug 1, 1979·European Journal of Pharmacology·J S AguilarE De Robertis
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H I Yamamura, S H Snyder
Feb 24, 1980·Brain Research·M J KuharE C Hulme
Mar 1, 1980·Journal of Neurochemistry·J M East, G R Dutton
May 16, 1980·European Journal of Pharmacology·J S AguilarE De Robertis
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Jan 1, 1985·Neurochemistry International·J S Aguilar, G G Lunt
Jan 1, 1989·The International Journal of Neuroscience·G N MoskovkinF Hajós

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