PMID: 88961Jan 1, 1978Paper

Ontogenesis of pyruvate kinase in the brain and liver tissues of the rat

P Gali, M Bourdin


The ontogenetic study of pyruvate kinase in the brain and liver tissues was performed in different batches of rats, from the foetus at the 13th day of gestation to the adult subject. -- According to the kinetic study, the shape of the curve is transformed from sigmoid to hyperbolic from the 13th day of foetal life to adulthood in the brain. Hill coefficient increases with the age of animal in the liver tissue. -- According to polyacrylamide gel isoelectrofocusing, a family of four, transitory or definite bands are detected in the foetal brain : they are well defined by their pHi : M4, M3, M2, M1 ; at the adult stage, M1 predominates, M2 is minor. Threee principal bands are distinguished in the liver : two are characteristic of foetal life (Lf and M2), one of adulthood (L). -- According to the immunochemical tests, there are antigenic determinants common to M1, M2, M3 and M4. The confrontation of the first two methods prompts the conclusion that the kinetic of the enzyme (and perhaps its function) varies with the animals age and is linked to its molecular structure. With the third method, it allows to stress the precociousness of the appearance of the common antigenic determinants, simultaneously with immature enzymatic forms. T...Continue Reading


Jan 25, 1977·Biochemistry·J M CardenasS Anderson
Jan 1, 1977·Biochimie·C Guguen-GuillouzoF Schapira
Dec 1, 1976·Journal of Neurochemistry·S W TolleJ M Cardenas
May 20, 1975·Biochemistry·J J StrandholmR D Dyson
Jan 26, 1972·Biochimica Et Biophysica Acta·O Vesterberg
Nov 21, 1972·Biochemistry·K H Ibsen, P Trippet
Jan 1, 1973·Biochimie·A Hatzfeld, F Schapira
Aug 1, 1973·Archives of Biochemistry and Biophysics·K H Ibsen, E Krueger
Aug 27, 1968·Biochimica Et Biophysica Acta·C J Masters


May 1, 1997·Trends in Pharmacological Sciences·J J HaganG H Poste
Apr 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jiangbin YeCraig B Thompson

Related Concepts

Antigenic Specificity
Fetal Structures
Antibody Dissociation
Isoelectric Focusing
R-Type Pyruvate Kinase
Rats, Laboratory

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