PMID: 9447938Feb 3, 1998Paper

Ontogenesis of substance P in the rat peripheral vestibular system

Hearing Research
D Demêmes, I V Ryzhova

Abstract

Ontogenesis of substance P (SP) in rat vestibular receptors between gestational day 17 (GD 17) and postnatal day 17 (PD 17) was investigated by immunocytochemistry. SP immunoreactivity was first detected in the afferent nerve fibers of the utricular and saccular maculae on GD 19 and thereafter at birth (PD 0) in the cristae. SP immunoreactivity presented a characteristic pattern. It was strictly confined to the slopes of cristae and peripheral regions of the maculae. The pattern of SP immunoreactivity changed during the maturation of the afferent innervation pattern between PD 4 and PD 9, resulting in fewer fibers being stained. Then, the number of immunostained calyces and small bouton endings increased. On PD 17 the distribution of SP was similar to that of the adult stage. We suggest that SP, present in the epithelium at critical stages of development, may be involved in the maturation of vestibular receptors.

References

Mar 1, 1990·Brain Research. Developmental Brain Research·G Desmadryl, A Sans
May 1, 1984·Acta Oto-laryngologica·J YlikoskiJ Lehtosalo
Aug 22, 1994·The Journal of Comparative Neurology·C J DechesneG Desmadryl
Jan 1, 1995·Acta Oto-laryngologica. Supplementum·S UsamiJ Kanzaki

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Citations

May 18, 2001·Brain Research. Developmental Brain Research·D DemêmesJ Raymond
Aug 7, 1998·Brain Research. Developmental Brain Research·D Demêmes, C Broca
Jul 3, 2009·Journal of Neurophysiology·Richard BoyleStephen M Highstein
Jul 21, 2004·Brain Research·Marie-Thérèse NicolasDanielle Demêmes
Sep 8, 2004·Hearing Research·Shunda R Irons-Brown, Timothy A Jones

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