PMID: 6965399Feb 1, 1980Paper

Ontogenic development of B-lymphocyte function and tolerance susceptibility in vivo and in an in vitro organ culture system

The Journal of Experimental Medicine
J M Teale, T E Mandel

Abstract

The maturation of B-lymphocyte function during fetal development was studied in vivo and in an in vitro organ culture system. The results indicated that the progenitors for 2,4-dinitrophenol (DNP)-specific B cells are present as early as 14 d of gestation in liver and possibly as early as 15 d in spleen. In addition, it was found that the organ culture system supports the development of B lymphocytes as measured by an increase in both the percentage of surface immunoglobulin-positive cells and the frequency of clonable DNP-specific B cells after culturing. The majority of anti-DNP-secreting clones resulting from the antigenic stimulation of fetal B cells produced only the IgM isotype, and the ability to secrete the IgG isotypes increased as a function of gestational age. Because fetal DNP precursors from spleens and livers that had been incubated in organ culture resulted in a greater proportion of clones secreting IgG compared with age-matched uncultured controls, it was concluded that the maturation with regard to the ability to secrete IgG can occur in vitro. In studies relating to the ontogenetic development of tolerance susceptibility, it was found that up to one-half of the DNP-specific B-cell precursors from livers and s...Continue Reading

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Citations

Jan 1, 1984·Developmental and Comparative Immunology·K S Landreth, P W Kincade
Dec 1, 1984·Immunobiology·R H GislerG Holländer
Jan 14, 2009·Immunology and Cell Biology·Werner Gurr, Christophe Viret
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G J Nossal, B L Pike
Nov 1, 1980·The Journal of Experimental Medicine·J Fung, H Köhler
Jun 1, 1981·The Journal of Experimental Medicine·D A RowleyI Lorbach
Apr 1, 1983·The Journal of Experimental Medicine·D Zharhary, N R Klinman
Oct 1, 1984·The Journal of Experimental Medicine·K A DenisO N Witte
Aug 1, 1988·The Journal of Experimental Medicine·H D Jeong, J M Teale
Jan 1, 1992·International Reviews of Immunology·J M Teale, C A Medina
Jun 30, 1983·Annals of the New York Academy of Sciences·J J CebraR D Shahin
Nov 27, 1980·Nature·J M Teale, N R Klinman
Jul 1, 1983·Journal of Cellular Physiology·B FaggC Le Bousse

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