PMID: 8963950Jan 1, 1996Paper

Ontogenic development of drug-metabolizing enzymes in male chicken liver

Canadian Journal of Physiology and Pharmacology
M CouletP Galtier

Abstract

The ontogenic study of the hepatic biotransformation enzymes revealed the early development of both oxidative and conjugative enzymes in male chickens ranging in age from 3 to 12 weeks. Although the rate of microsomal cytochrome P450 reactions progressively increased during the first 9 weeks, it decreased thereafter. Furthermore, the proteins revealed by the antibodies to anti-cytochrome P450 1A2, 2B4, 2C7, and 3A4 appeared to be constitutively expressed. Hepatic monooxygenases were characterized by different developmental patterns. The demethylase activities increased progressively up to 9 weeks, then they declined, in 12 weeks reaching the activity level observed in 3-week-old chickens. In contrast, alkoxyresorufin O-dealkylases and benzopyrene hydroxylase activities continued to increase with age. Significant variability was noted for aniline hydroxylase. Among conjugation enzymes, UDP-glucuronyltransferase towards p-nitrophenol and isoniazid N-acetyltransferase activities increased with the age of the fowl, but with different profiles. Concerning glutathione S-transferase accepting 1-chloro-2,4-dinitrobenzene or 1,2-dichloro-4-nitrobenzene, the chickens aged from 3 to 9 weeks were less well developed in this enzyme than 12-...Continue Reading

Citations

Jun 29, 2010·Research in Veterinary Science·Ling-Ling ZhangShan-Xiang Jiang
Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·K A Cortright, A L Craigmill
Nov 11, 2010·Journal of Veterinary Pharmacology and Therapeutics·L L ZhangS X Jiang
Apr 18, 2008·European Journal of Pharmacology·Johanna Fink-Gremmels
Mar 5, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Katarzyna Błaszczak-ŚwiątkiewiczElżbieta Mikiciuk-Olasik

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