Ontogensis of spermatozoa autoantigens in guinea pigs.

Differentiation; Research in Biological Diversity
I Radu, G A Voisin

Abstract

The ontogenetic appearance of three independant spermatozoa autoantigens (S, P and T) has been studied in guinea pig germinal cells by immunofluorescence and comparison with cytology and histological structures during early maturation of seminiferous tubule cells. The maturation of 120 testes from 60 guinea pigs studied from day 1 to day 50 after birth has shown an evolution in 3 periods. During the first, or negative, period (day 1 to day 25), only spermatogonia (from day 1) and spermatocytes I (from day 16) are present. No significant PAS-positive formations are seen and no autoantigen is detected. During the second, or transitional, period (day 26 to 29), spermatocytes II and spermatids appear as well as paranuclear PAS-positive golgian proacrosomal and acrosomal granules. At the same time, the three autoantigens S, P and T are detected on the same PAS-positive formations with a frequency that increases from day to day. During the third, or positive, period (from day 30) all testes present cells with PAS-positive formation, progressive maturation of acrosomes in spermatids and appearance of spermatozoa (present on day 39) leading to the adult structure of seminiferous tubules. The three autoantigens are constantly present du...Continue Reading

References

Jan 1, 1960·International Archives of Allergy and Applied Immunology·S KATSH

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Citations

Sep 1, 1981·Journal of Reproductive Immunology·R P EricksonM Butley
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R P EricksonA Salkeld
Sep 1, 1989·Neuroscience and Behavioral Physiology·T G VoznesenskayaN M Fokina
Jan 1, 1989·Archives of Andrology·D K Kapur, G K Ahuja

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