Ontogeny and distribution of cells in B lineage in the American leopard frog, Rana pipiens

Developmental and Comparative Immunology
L D Zettergren

Abstract

Two-color immunofluorescence techniques were used in order to trace the development and distribution of cells expressing immunoglobulin in Rana pipiens. Evidence is provided which suggests that (i) embryo-larval urogenital tissues are sites of generation of cells in B lineage, (ii) during ontogeny, there is a sequential expression of immunoglobulin isotypes on B cell surfaces, (iii) larvae are able to produce the full range of immunoglobulin clases found in adults, and (iv) at least two subpopulations of lymphocytes exist in Rana pipiens, sIg+ and sIg-; thymocytes and presumably peripheral T cells lack conventional surface immunoglobulin. Some ontogenetic and phylogenetic implications are discussed.

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Citations

Jan 1, 1985·Developmental and Comparative Immunology·K Natarajan, V R Muthukkaruppan
Jan 1, 1988·Developmental and Comparative Immunology·L D ZettergrenL S Schmid
Jan 1, 1990·Developmental and Comparative Immunology·S O el Deeb, A H Saad
Sep 1, 1993·Developmental and Comparative Immunology·A CastilloA J Villena
Jan 1, 1991·Toxicology Letters·L D ZettergrenJ G Zettergren
May 14, 2005·Fish & Shellfish Immunology·J H W M RomboutG Scapigliati
Nov 18, 2000·Fish & Shellfish Immunology·N M dos SantosJ H Rombout
Jan 27, 2004·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Baya BelaïdMireille Dorizzi

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