Ontogeny and epithelial-stromal interactions regulate IGF expression in the ovine mammary gland

Molecular and Cellular Endocrinology
R C HoveyT McFadden

Abstract

Although the insulin-like growth factors (IGF-I and -II) have been implicated in the stimulation of mammogenesis, little is known of their regulation in the mammary gland. In this study we removed epithelial tissue from one of the two mammary glands of 1-week-old ewe lambs and examined IGF-I and -II mRNA expression during postnatal development in both the intact mammary gland and in the gland cleared of epithelial tissue. Expression of IGF-I mRNA was highest at 6 and 10 weeks of age, coincident with the prepubertal phase of rapid mammary growth, then declined and remained low until expression increased during late pregnancy. IGF-I mRNA was more abundant in the mammary fat pad adjacent to parenchyma (MFP) than in the contralateral fat pad that had been surgically cleared of epithelium (CFP). The level of IGF-II mRNA in parenchyma was highest at 1-23 weeks of age due to an increase in the abundance of specific mRNAs. Expression was lower in the fat pads, with generally higher levels in the intact MFP than the CFP, and in these tissues IGF-II expression was shown to increase with age between 6 and 23 weeks. We also investigated the influence of the ovary and estrogen on the expression of IGFs. While IGF-I mRNA abundance was unaffe...Continue Reading

References

Jan 1, 1977·The Journal of Endocrinology·S HandwergerR E Fellows
May 11, 1991·Molecular and Cellular Endocrinology·D LeRoith, C T Roberts
Aug 1, 1991·Endocrine Reviews·P A KellyM Edery
Sep 10, 1990·Molecular and Cellular Endocrinology·S D HauserG G Krivi
Sep 12, 1989·Nucleic Acids Research·V Barbu, F Dautry
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Jan 1, 1994·Breast Cancer Research and Treatment·M J EllisK J Cullen
Jan 1, 1996·Journal of Mammary Gland Biology and Neoplasia·G R Cunha, Y K Hom

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Citations

Aug 19, 2010·Journal of Mammary Gland Biology and Neoplasia·Russell C Hovey, Lucila Aimo
Jun 14, 2005·Domestic Animal Endocrinology·F VangroenwegheC Burvenich
Jul 31, 2001·Molecular and Cellular Endocrinology·R C HoveyT B McFadden
Nov 30, 2000·Breast Cancer Research and Treatment·C F SingerK J Cullen
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Apr 17, 2012·Seminars in Cell & Developmental Biology·Ashley R RowsonRussell C Hovey
Jul 7, 2005·Domestic Animal Endocrinology·R M AkersS D Berry
Oct 13, 2018·Journal of Animal Science·Takele FeyeraPeter Kappel Theil
May 23, 2007·Journal of Dairy Science·E E ConnorA V Capuco
Jan 30, 2003·Molecular Endocrinology·Russell C HoveyBarbara K Vonderhaar

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