Ontogeny of 5-HT neurons in the brainstem of the lamprey, Petromyzon marinus

The Journal of Comparative Neurology
Myriam AntriR Dubuc

Abstract

This study examined the spatial and temporal distribution of serotonin-immunoreactive (5-HT-ir) neurons in the brainstem of Petromyzon marinus at three developmental stages, larval, postmetamorphic, and reproductive. Computer-assisted 3-D reconstructions were made of the three main 5-HT-ir neuron groups. The rostralmost brainstem group was located near the posterior commissure, the second group at the isthmus, and the third group in the bulbar area. For each of those groups, the distribution of the 5-HT-ir neurons was very similar in the three developmental stages examined, suggesting that the 5-HT system is relatively mature early in larval animals. The soma of 5-HT-ir neurons increased in size and their dendritic fields increased in complexity with development. Furthermore, the number of 5-HT-ir neurons in each group increased significantly from the larval to the reproductive stage. To determine whether this was due to the genesis of 5-HT neurons, bromodeoxyuridine (BrdU) was injected into larval, metamorphosing, and postmetamorphic lampreys. These experiments revealed a few neurons colocalizing BrdU and 5-HT in metamorphosing animals. Taken together, the present results suggest that 5-HT neurons increase in number during mat...Continue Reading

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Citations

Oct 12, 2012·Brain Structure & Function·María Eugenia Cornide-PetronioMaría Celina Rodicio
Jun 4, 2011·Journal of Chemical Neuroanatomy·Christina Lillesaar
Jul 8, 2008·Journal of Chemical Neuroanatomy·Antón Barreiro-IglesiasMaría Celina Rodicio
May 9, 2007·Journal of Chemical Neuroanatomy·Xesús M AbaloMaría Celina Rodicio
Nov 26, 2008·The Journal of Comparative Neurology·Antón Barreiro-IglesiasMaría Celina Rodicio
Aug 16, 2008·The European Journal of Neuroscience·Myriam AntriRéjean Dubuc
Oct 18, 2008·The Journal of Comparative Neurology·Iván CarreraIsabel Rodríguez-Moldes
Apr 6, 2016·Frontiers in Neural Circuits·Gheylen DaghfousRéjean Dubuc
Jan 16, 2008·The Journal of Comparative Neurology·Verona Villar-CerviñoMaría Celina Rodicio
May 14, 2020·Journal of Neurophysiology·Tyler R SizemoreAndrew M Dacks
Feb 3, 2019·Disease Models & Mechanisms·Daniel Sobrido-CameánAntón Barreiro-Iglesias
Jul 31, 2021·Respiratory Physiology & Neurobiology·Donatella MutoloElenia Cinelli

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