Ontogeny of B lymphocyte function. VIII. Failure of thymus cells from aged donors to induce the functional maturation of B lymphocytes from immature donors

European Journal of Immunology
M R SzewczukG W Siskind

Abstract

The role of thymus cells in mediating a step in the ontogeny of the capacity of the B cell population to produce a heterogeneous, high-affinity, primary, plaque-forming cell (PFC) response was further investigated. It was shown that the thymus acquires the capacity to facilitate this step in B cell differentiation between 3 and 4 weeks of age in C57BL/6 mice. This corresponds to the age at which te splenic B cell population of these mice naturally acquires the capacity to produce high-affinity PFC. The differentiation of the B cell population. It was further shown that regulates this step in the cells to facilitate the maturation of B cell population. It was further shown that the ability of thymus cells to facilitate the maturation of the B cell population decreases with age and is already markedly reduced in 30-week-old, long-lived, C57BL/6 mice. A qualitative or quantitative decrease in thymic function may thus be responsible for age-related changes in the function of the B cell population.

References

Jun 1, 1977·Cellular Immunology·R E CallardL K Waters
Oct 1, 1974·Immunochemistry·C DeLisi, B Goldstein
Oct 11, 1974·Nature·D FriedmanA Globerson
Feb 1, 1966·Acta Medica Scandinavica·U AxelssonJ Hällén
Jan 1, 1974·The Journal of Clinical Investigation·M E Weksler, T H Hütteroth
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Sep 15, 1980·Cellular Immunology·J DobkenG W Siskind

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Citations

Feb 26, 2000·Vaccine·M E Weksler
Jan 1, 1988·Experimental Aging Research·D G Hazzard, J Soban
Oct 1, 1981·Hospital Practice·M E Weksler

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