Ontogeny of blood pressure and the renin-angiotensin-aldosterone system. Sequential studies in the newborn lamb

Circulation Research
T A WilsonR M Carey

Abstract

To test the hypothesis that the rise in arterial pressure occurring with maturation is due to an increase in the vascular responsiveness to angiotensin II, sequential cumulative doses of angiotensin II were infused intravenously into chronically catheterized newborn lambs maintained on a constant, weight-adjusted sodium intake from birth to 8 weeks of age. Basal mean arterial pressure correlated with both age and weight, but age was a stronger determinant of mean arterial pressure than was weight. No change in the mean arterial pressure response to angiotensin II occurred with maturation. Basal plasma renin activity and plasma aldosterone concentrations were low and did not change significantly with age. Therefore, in the newborn lamb in the sodium replete state, age is a better determinant of arterial pressure than is weight. However, an age-related change in vasoconstrictor responsiveness to angiotensin II does not occur and, therefore, cannot account for the rise in arterial pressure that is observed with maturation.

References

Aug 1, 1979·Kidney International·K J Van AckerH M Neels
Mar 1, 1977·Pediatric Research·M C Raux-EurinF Girard
Jul 1, 1977·The Journal of Pediatrics·F Broughton Pipkin, O R Smales
Aug 1, 1976·The Journal of Pediatrics·H P StalkerT A Kotchen
Jul 1, 1976·Archives of Disease in Childhood·M J DillonM de Swiet
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J SassardJ F Cier
May 1, 1975·The Journal of Pediatrics·R M LauerW R Clarke
Jan 1, 1975·British Medical Bulletin·J C Mott
Jun 1, 1976·Endocrinology·G H WilliamsL M Braley
Jul 1, 1972·The American Journal of Physiology·F HébertP Biron
Jan 1, 1974·Pflügers Archiv : European journal of physiology·I Pohlová, J Jelínek
Oct 1, 1971·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·F B Pipkin
Feb 1, 1980·Pediatric Research·S R Siegel, D A Fisher
Jan 1, 1980·Advances in Experimental Medicine and Biology·A Moore
Feb 1, 1965·The Journal of Clinical Investigation·D L BOATMANM J BRODY

❮ Previous
Next ❯

Citations

Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·N M Buckley
Nov 20, 2008·Reproductive Sciences·Lucia KantorowiczJames C Rose
Mar 24, 1999·Pediatric Research·B E Cox, C R Rosenfeld
Aug 24, 2002·Pediatric Research·Sithembiso C VelaphiCharles R Rosenfeld
May 10, 2005·Pediatric Research·Sithembiso C VelaphiCharles R Rosenfeld
Dec 3, 2014·Vascular Pharmacology·Angela Elena Vinturache, Francine Gabriel Smith
May 30, 2014·Physiological Reports·Angela E Vinturache, Francine G Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
H GurdalH O Onaran
Pediatrics International : Official Journal of the Japan Pediatric Society
Toshihiko ShirakawaHiroyuki Moriuchi
Annals of Internal Medicine
D H Streeten, G H Anderson
© 2021 Meta ULC. All rights reserved