Ontogeny of calbindin immunoreactivity in the human hippocampal formation with a special emphasis on granule cells of the dentate gyrus

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Hajnalka AbrahámL Seress

Abstract

Calbindin (CB) is a calcium-binding protein that is present in principal cells as well as in interneurons of the hippocampal formation of various species including humans. Studies with transgenic mice revealed that CB is essential for long-term potentiation and synaptic plasticity which are the cellular basis of learning and memory. In a previous study we have shown that CB expression in granule cells of the dentate gyrus correlates with the functional maturation of the hippocampal formation in the rat. In the present study we examined the ontogeny of CB using immunohistochemistry in the human hippocampal formation paying special attention to the granule cells of the dentate gyrus. As early as the 14(th) week of gestation (GW), CB was being expressed by pyramidal cells of CA1-3 regions in the deepest cell rows of the pyramidal layer towards the ventricular zone. Later, CB sequentially appears in more superficial cell rows. After midgestation, CB disappears from CA3 pyramidal neurons. Expression of CB by granule cells starts at the 22(nd)-23(rd) GW, first by the most superficial neurons of the ectal end of the dorsal blade. At the 24(th) GW, CB is expressed by granule cells of the crest and medial portion of the ventral blade wh...Continue Reading

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Citations

Aug 29, 2013·Cell Biology and Toxicology·Valeria Maria PiccoliniGraziella Bernocchi
May 15, 2012·Micron : the International Research and Review Journal for Microscopy·Marcus HezelFaramarz Dehghani
Dec 14, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hajnalka ÁbrahámLászló Seress
Apr 27, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hajnalka AbrahámLászló Seress
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Dec 23, 2016·Cellular and Molecular Neurobiology·Petr M MasliukovJean-Pierre Timmermans
Nov 28, 2014·The Journal of Veterinary Medical Science·Tae-Ho ChungChoong Hyun Lee
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Feb 5, 2021·Hippocampus·Vanessa DespotovskiRita Machaalani

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