Ontogeny of defensive behavior and analgesia in rat pups exposed to an adult male rat

Physiology & Behavior
C P Wiedenmayer, G A Barr

Abstract

Aversive situations may reduce nociception. The mechanism underlying such analgesia has been suggested to involve the interaction between the two separate but interconnected motivational systems "defense" and "pain." To determine the developmental course of defense and nociception, these processes were analyzed during early ontogeny in rats. To elicit a defensive reaction, a huddle of preweanling rat pups was exposed to an unfamiliar, unrelated adult male, or, for comparison, to the mother. On postnatal Day 7 the pups did not show a behavioral reaction to the presence of the mother or the male, and no reduction in nociceptive threshold in a thermal paw withdrawal test. On Day 14, pups in the presence of the male stopped ongoing behaviors and became immobile, and showed reduced paw withdrawal after the exposure. At Day 21, 22 pups of 32 became immobile when exposed to the male, whereas 10 pups explored the partition separating them from the male. Neither group showed reduced paw withdrawal. Immobility was considered a defensive reaction because it reduces auditory and visual cues and therefore the probability of being detected. The developmental course of immobility seems to reflect both the changes in threat imposed on the pups...Continue Reading

References

Nov 1, 1975·Animal Behaviour·J Altman, K Sudarshan
Jan 1, 1988·Annual Review of Psychology·D C Blanchard, R J Blanchard
Dec 1, 1988·Brain Research Bulletin·R J Hamm, J S Knisely
Jan 1, 1988·Physiology & Behavior·J A Mennella, H Moltz
Jan 1, 1986·Annals of the New York Academy of Sciences·K A MiczekL Shuster
Jun 1, 1985·Behavioral Neuroscience·M S Fanselow
Mar 1, 1980·Developmental Psychobiology·A C Collier, R C Bolles
Oct 1, 1993·Reviews in the Neurosciences·M L Brandão
Sep 1, 1996·Progress in Neurobiology·J Sandkühler

❮ Previous
Next ❯

Citations

May 4, 2007·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Regina M Sullivan
Jan 27, 2004·Physiology & Behavior·D T HubbardR J Blanchard
Apr 25, 2000·Brain Research. Developmental Brain Research·C P WiedenmayerG A Barr
Nov 13, 2001·Behavioural Brain Research·C P Wiedenmayer, G A Barr
Jul 3, 2003·Neurophysiologie clinique = Clinical neurophysiology·René Misslin
Dec 17, 2003·Behavioral Neuroscience·Marianne WeberRick Richardson
Feb 17, 2000·Annals of the New York Academy of Sciences·G A Barr, J E Zadina
Feb 21, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patricia A KabitzkeChristoph P Wiedenmayer
Aug 17, 2001·Developmental Psychobiology·C P Wiedenmayer, G A Barr
Jan 17, 2012·Behavioural Brain Research·R HacquemandG Brand
Apr 24, 2012·The Journal of Comparative Neurology·Loïc J ChareyronPierre Lavenex
Mar 6, 2004·Annals of the New York Academy of Sciences·Christoph P WiedenmayerGordon A Barr
Apr 12, 2016·Ecology and Evolution·Heather R SpenceHarry N Shair
Jun 12, 2014·Developmental Psychobiology·Harry N Shair
Jan 11, 2011·Behavioural Processes·Patricia A Kabitzke, Christoph P Wiedenmayer
Apr 26, 2011·Neurobiology of Learning and Memory·Patricia A KabitzkeChristoph Wiedenmayer
Aug 30, 2016·Pharmacology, Biochemistry, and Behavior·Sara L Stockman, Margaret M McCarthy
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Stephanie MoriceauRegina M Sullivan
Sep 17, 2016·Learning & Memory·Julie Boulanger BertolusRegina M Sullivan
Feb 12, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sarah M ClintonMatthew E Glover

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.