PMID: 3765334Jun 1, 1986Paper

Ontogeny of gut-associated lymphoid tissue (GALT) in the dogfish Scyliorhinus canicula L

Veterinary Immunology and Immunopathology
S HartJ E Harris

Abstract

Cartilaginous fish occupy a fundamental position in vertebrate phylogeny and it is likely that this group has retained some of the ancestral immune mechanisms. The ontogeny of GALT has received little attention in elasmobranchs and this study correlates this development with morphological differentiation, development of other lymphoid organs, exposure to seawater and transition from yolk dependence to exogenous food as a source of nutrient. GALT was first represented by individual lymphocyte-like and macrophage-like cells in the lamina propria. In later stages accumulations and intraepithelial leucocytes were recorded prior to hatching. The size of accumulations and the number of lymphocyte and macrophage-like cells infiltrating the lamina propria and epithelium increased in fish as they became dependent upon an exogenous diet. Although GALT developed after the thymus and lymphoid-like tissue in the kidney and at approximately the same time as the epigonal, Leydig and spleen, the source of cells populating the gut is unknown. Plasma cells and granulocytes were not observed in the developing fish until 6 months post-hatch after which the fish had a similar GALT distribution and content to the adult fish.

References

Nov 1, 1978·The Journal of Experimental Medicine·A J Husband, J L Gowans
Jul 29, 1977·Science·R F Doolittle
Apr 1, 1981·Immunology Today·G W Warr
Feb 1, 1985·Immunology Today·P B ErnstJ Bienenstock

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Citations

Jan 1, 1986·Developmental and Comparative Immunology·S HartJ E Harris
Jan 1, 1988·Developmental and Comparative Immunology·S HartT H Grayson
May 14, 2005·Fish & Shellfish Immunology·J H W M RomboutG Scapigliati
Jan 23, 1999·Immunological Reviews·J D Hansen, A G Zapata
Jul 28, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Masayuki Hirano
Nov 1, 1993·Developmental and Comparative Immunology·P Lloyd-Evans
Nov 24, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Randal K Buddington, Ashild Krogdahl

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