Ontogeny of human brain dopamine receptors. I. Differential expression of [3H]-SCH23390 and [3H]-YM09151-2 specific binding

Brain Research. Developmental Brain Research
A S UnisD M Dorsa

Abstract

Dopamine receptor expression in human fetal forebrain (between 6 and 20 weeks of gestation) was measured using tissue-slice receptor autoradiography with the D1-like and D2-like antagonists [3H]-SCH23390 and [3H]-YM09151-2, respectively. Tissue sections were assayed in saturation studies and examined for age- and sex-related changes in Bmax. We made the following observations: (1) the ages at which D1- and D2-like receptors were first expressed in whole forebrain sections could be reliably identified but were not significantly different from one another (gestational age 65 days for D1- vs. 72 days for D2-like receptors); (2) age-related increases in both D1- and D2-like receptors were demonstrated in forebrain and, from the middle of the first to the middle of the second trimester, the Bmax for each ligand increased by an order of magnitude after the onset of the specific binding site's expression; (3) age-related increases in D1-like receptors, but not D2-like receptors, could be demonstrated in cortex; and, (4) in one case of trisomy 18, the Bmax for [3H]-SCH23390 was significantly elevated above the 95% confidence interval when compared to an age-regressed normal sample. Although D2-like receptor density significantly increa...Continue Reading

Citations

Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
Jan 29, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ana Carolina Monteiro de Souza LimaBruno Rezende Souza
May 21, 1999·Journal of Neuroscience Research·M A ElwanN Sakuragawa
Jan 22, 2009·British Journal of Pharmacology·Kwok Ho Christopher ChoyMaarten van den Buuse

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