PMID: 9438513Jan 23, 1998Paper

Ontogeny of hypothalamic corticotropin-releasing factor and anterior pituitary pro-opiomelanocortin expression in male and female offspring of alcohol-exposed and adrenalectomized dams

Alcoholism, Clinical and Experimental Research
F AirdE Redei

Abstract

This study was designed to determine whether the previously described sexually dimorphic changes in rat hypothalamic corticotropin-releasing factor (CRF) and anterior pituitary pro-opiomelanocortin (POMC) mRNA expression in response to fetal alcohol exposure (FAE) are present prepubertally and whether they are altered by maternal adrenalectomy. Hypothalamic CRF and anterior pituitary POMC mRNA levels were determined in male and female offspring of adrenalectomized (ADX) and sham-adrenalectomized (Sham) dams exposed to alcohol (FAE) or a pair-fed (PF) control diet during the last 2 weeks of gestation. CRF and POMC mRNA levels were measured by Northern blotting at 1, 7, 14, and 21 days of age. In offspring of control PF dams, CRF mRNA levels increased faster in females, increasing by day 7, followed by a decrease at days 14 and 21, whereas in males there was a gradual increase from days 1 to 21. FAE altered the ontogenic profile of CRF mRNA in female offspring by delaying and exaggerating the rise of CRF expression to day 14, but produced no effect in males. Maternal adrenalectomy, combined with FAE, resulted in an early rise of CRF mRNA on day 14 in male offspring. In females, the combined ADX/FAE treatment resulted in significa...Continue Reading

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Citations

Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·S BarronJ A Willford
Mar 25, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura J SittigEva E Redei
Sep 1, 2007·Alcoholism, Clinical and Experimental Research·Maria M GlavasJoanne Weinberg
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Sang Soo KangCatherine Rivier
Dec 1, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Travis J Worst, Kent E Vrana
Apr 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Korami DembeleB L Grégoire Nyomba

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