Abstract
This study was designed to determine whether the previously described sexually dimorphic changes in rat hypothalamic corticotropin-releasing factor (CRF) and anterior pituitary pro-opiomelanocortin (POMC) mRNA expression in response to fetal alcohol exposure (FAE) are present prepubertally and whether they are altered by maternal adrenalectomy. Hypothalamic CRF and anterior pituitary POMC mRNA levels were determined in male and female offspring of adrenalectomized (ADX) and sham-adrenalectomized (Sham) dams exposed to alcohol (FAE) or a pair-fed (PF) control diet during the last 2 weeks of gestation. CRF and POMC mRNA levels were measured by Northern blotting at 1, 7, 14, and 21 days of age. In offspring of control PF dams, CRF mRNA levels increased faster in females, increasing by day 7, followed by a decrease at days 14 and 21, whereas in males there was a gradual increase from days 1 to 21. FAE altered the ontogenic profile of CRF mRNA in female offspring by delaying and exaggerating the rise of CRF expression to day 14, but produced no effect in males. Maternal adrenalectomy, combined with FAE, resulted in an early rise of CRF mRNA on day 14 in male offspring. In females, the combined ADX/FAE treatment resulted in significa...Continue Reading
References
May 1, 1992·Alcohol·J Weinberg
May 1, 1990·Neurotoxicology and Teratology·C D DriscollE P Riley
Feb 1, 1989·Alcoholism, Clinical and Experimental Research·J Weinberg
Jun 1, 1989·Alcoholism, Clinical and Experimental Research·E RedeiR F McGivern
Aug 1, 1989·Alcoholism, Clinical and Experimental Research·P Angelogianni, C Gianoulakis
Aug 1, 1986·Alcoholism, Clinical and Experimental Research·L R NelsonB J Branch
Oct 1, 1988·Alcoholism, Clinical and Experimental Research·J Weinberg
May 1, 1987·Molecular Endocrinology·R C ThompsonE Herbert
Apr 1, 1988·Alcoholism, Clinical and Experimental Research·R F McGivernE Redei
Jun 1, 1987·Alcoholism, Clinical and Experimental Research·J Weinberg, S Bezio
Mar 25, 1986·Nucleic Acids Research·K TokunagaS Sakiyama
Jul 1, 1986·Alcohol·A N TaylorR E Poland
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·A N TaylorN Kokka
Jan 1, 1982·Psychoneuroendocrinology·A N TaylorR E Poland
Jan 1, 1980·Endocrinology·J Weisz, I L Ward
Dec 1, 1993·Alcoholism, Clinical and Experimental Research·R F McGivernE Redei
Dec 31, 1995·Journal of Neuroimmunology·J M BakkerE P van Rees
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·M E WilsonR J Handa
Feb 1, 1996·Alcoholism, Clinical and Experimental Research·J WeinbergC Gianoulakis
Dec 1, 1996·Neuroendocrinology·N S LevittJ R Seckl
Jun 18, 1997·Brain Research. Developmental Brain Research·I HalaszE Redei
Apr 1, 1992·Molecular and Cellular Neurosciences·S Lee, C Rivier
Citations
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·S BarronJ A Willford
Mar 25, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura J SittigEva E Redei
Jan 2, 2009·Journal of Applied Physiology·Qiuli LiuMargaret T T Wong-Riley
May 26, 2012·Progress in Neurobiology·Yong LiLubo Zhang
Jul 1, 2008·Neuroscience·I Y ChoiC Rivier
Feb 13, 2008·Journal of Neuroendocrinology·J WeinbergK G C Hellemans
Sep 1, 2007·Alcoholism, Clinical and Experimental Research·Maria M GlavasJoanne Weinberg
Jun 9, 2005·Brain Research. Developmental Brain Research·Kara I GabrielJoanne Weinberg
Sep 8, 2015·Neuroscience·N LanJ Weinberg
Jul 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·D O'ReganM C Holmes
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Sang Soo KangCatherine Rivier
Dec 1, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Travis J Worst, Kent E Vrana
Apr 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Korami DembeleB L Grégoire Nyomba