Ontogeny of mu opioid agonist anti-nociception in postnatal rats

Brain Research. Developmental Brain Research
S R ThorntonF L Smith

Abstract

Mu opiate agonists morphine, fentanyl and meperidine are administered short-term to pediatric patients, from the neonatal period through adolescence. However, there has been no assessment of the effect of age on the analgesic efficacy or the concentration-response relationship for these opioids in human pediatric patients. Few studies in animals have correlated opioid anti-nociception and tissue levels of these opioids commonly administered to pediatric patients. The present study was conducted to examined the role of age on opioid anti-nociceptive potency and efficacy and brain and plasma opioid levels to provide predictive information on the effect of opioids in developing humans. Administration of trace amounts of tritiated drug with anti-nociceptive doses of unlabeled drug was used for the assessment of anti-nociception in the tail-flick test and for the measurement of brain and plasma drug equivalent levels in postnatal rats (PND 3-21). Morphine and fentanyl were completely efficacious in all postnatal ages examined, although age-related differences in drug potency, as well as, differences in brain and plasma levels were observed. There was a good correlation between morphine (r = 0.96) and fentanyl (r = 0.89) ED(50) value...Continue Reading

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Citations

Sep 21, 2001·Indian Journal of Pediatrics·M Yaster, D G Nichols
Jan 9, 1999·European Journal of Pharmacology·S R Thornton, F L Smith
Jan 22, 2003·Physiology & Behavior·Tania L Roth, Regina M Sullivan
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·S R ThorntonF L Smith
Mar 8, 2002·The Journal of Burn Care & Rehabilitation·F J StoddardJ A J Martyn
Oct 27, 2004·The Journal of Pain : Official Journal of the American Pain Society·Wendy F SternbergLaura Scorr
May 14, 2004·European Journal of Pharmacology·Jing-Gen LiuK J S Anand
Aug 16, 2005·Brain Research. Developmental Brain Research·Andrè LaferrièreImmanuela Ravè Moss
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Malini E SinghPaul E Mallet
Jul 25, 2021·International Journal of Molecular Sciences·Cécile Dromard BerthézèneAnne Lorsignol

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