Ontogeny of mucosal immunity--environmental and behavioral influences

Brain, Behavior, and Immunity
A J Husband, M Gleeson

Abstract

Since mucosal surfaces represent the interface between the host and the environment and are the most common portal of pathogen entry, early development of functional mucosal immune defense is essential for survival. The development of mucosal immune function is profoundly influenced by maternal, environmental, and behavioral factors and although the impact of these is greatest during the prenatal and immediately postnatal periods, their influence extends beyond this period and patterns of development in postnatal life determine many of the immune outcomes in later life. This review will correlate information regarding age-related changes occurring in mucosal-associated lymphoid tissue from a variety of animal models and in humans and will explore how the interactions which exist between the immune and neuroendocrine systems orchestrate these effects. In particular the role of prenatal and postnatal stressors, feeding patterns, nutritional factors, infections, and exposure to allergens and toxins are addressed. A clear understanding of the way in which these factors interact to influence development and control of mucosal immune function will assist in the design of neonatal vaccination and disease management strategies.

Citations

Aug 18, 2000·The Proceedings of the Nutrition Society·D Kelly, A G Coutts
Jul 30, 2002·British Journal of Sports Medicine·L DimitriouM Doherty
Jun 30, 2012·American Journal of Physical Anthropology·Elizabeth M Miller, Daniel S McConnell
Aug 16, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Hirobumi GunjiStephen J Hopkins
Aug 8, 2015·Clinics in Perinatology·Akhil Maheshwari
Feb 11, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Sylvia BrugmanHuub F J Savelkoul
Aug 25, 2004·FEMS Immunology and Medical Microbiology·Maree Gleeson, Allan W Cripps
Feb 24, 2000·American Journal of Physical Anthropology·D C Merrett, S Pfeiffer
Feb 28, 2018·Environmental Health : a Global Access Science Source·Morgan YeBrenda Eskenazi
Sep 29, 2011·Cellular and Molecular Life Sciences : CMLS·Silvia StockingerCécilia Chassin
Mar 3, 1998·Nutrition Reviews·P Brandtzaeg
Mar 19, 2005·Pediatric Research·Francisco J Pérez-CanoMargarida Castell
Feb 1, 2005·Annals of the New York Academy of Sciences·Daniel Sousa MucidaMomchilo Russo
Feb 26, 2000·Developmental and Comparative Immunology·S González-Ariki, A J Husband

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