Ontogeny of platelet function

Blood Advances
Andreas MargrafMarkus Sperandio

Abstract

Although the hemostatic potential of adult platelets has been investigated extensively, regulation of platelet function during fetal life is less clear. Recent studies have provided increasing evidence for a developmental control of platelet function during fetal ontogeny. Fetal platelets feature distinct differences in reactive properties compared with adults. These differences very likely reflect a modified hemostatic and homeostatic environment in which platelet hyporeactivity contributes to prevent pathological clot formation on the one hand but still ensures sufficient hemostasis on the other hand. In this review, recent findings on the ontogeny of platelet function and reactivity are summarized, and implications for clinical practice are critically discussed. This includes current platelet-transfusion practice and its potential risk in premature infants and neonates.

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Citations

Oct 23, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas Margraf, Alexander Zarbock
Aug 20, 2019·Expert Review of Hematology·Suzanne F Fustolo-GunninkEnrico Lopriore
Jan 14, 2021·Cellular and Molecular Life Sciences : CMLS·Naoshi Sugimoto, Koji Eto
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Andreas Margraf, Markus Sperandio
Mar 7, 2021·International Journal of Molecular Sciences·Julia Peñas-MartínezFrancisca Ferrer-Marín
Aug 8, 2021·International Journal of Molecular Sciences·Linda KrischDirk Strunk
Aug 17, 2021·Platelets·Francisca Ferrer-Marín, Martha Sola-Visner
Aug 24, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Belay Tesfamariam
Sep 19, 2021·Stem Cells Translational Medicine·Cuicui LiuJiaxi Zhou

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